羟基喜树碱联合岩舒注射液胸腔内注射治疗癌性胸水30例

Effect of Hydroxycamptothecin and Yanshu Injection by Intrapleural Infusion in Treatment of 30 Cases Malignant Pleural Effusions

目的:观察羟基喜树碱联合岩舒注射液胸腔内注射治疗癌性胸水的疗效。方法:将60例患者依数字随机法分为两组,各30例。观察组以羟基喜树碱10 mg、岩舒注射液30 mL分别注入胸腔,对照组用羟基喜树碱10 mg注入胸腔。结果:观察组CR17例,PR8例,NC5例;对照组CR8例,PR14例,NC8例。两组比较,CR有显著性差异(P<0.05)。同时观察组白细胞减少的发生率0级与Ⅱ级低于对照组(P<0.05)。结论:羟基喜树碱与岩舒注射液胸腔注射治疗癌性胸水有协同迭加作用,能提高疗效,减轻毒副作用。

Objective ：To investigate the clinical effect of hydroxycamptothecin and YanShu injection by intrapleural infusion in treatment of malignant pleural effusions. Methods： Using the randomized controlled methods, the patients in observation group were received the hydroxycamptothecin 10 mg and YanShu injection 30ml by intrapleural infusion and those in control group were received YanSha injection 30ml only. Results：In observation group 17 patients were CR, 8 patients were PR and 5 patients were NC; in control group 8 patients were CR, 14 patients were PR and 8 patients were NC; in the two groups, CR had significant difference. At the same time, thoses observation group had lower incidence rates in leucopenia than control group. Conclusion： hydroxycamptothecin and YanShu injection by intrapleural infusion in treatment of malignant pleural effusions have synergistic effect and could improve the curative effect, even reduce side effects.