HLA-B27阳性强直性脊柱炎患者的临床特征分析

Analysis of Clinical Features of Patients with Ankylosing Spondylitis and Positive HLA-B27

目的对白细胞抗原HLA-B27阳性强直性脊柱炎(ankylosing spondylitis,AS)患者的临床特征进行分析。方法收集1 340例HLA-B27阳性AS患者的年龄、性别、家族遗传史情况,并检测其血沉(ESR)、血清类风湿因子(RF)、人抗链球菌溶血素O(ASO)水平。结果HLA-B27阳性AS患者中男女人数比例为4.15∶1,就诊平均年龄为31.75岁,有明显的家族遗传史者占87.31%;ESR≥20mm/h的占42.5%,ASO≥500 U的占20%,RF仅1例为阳性。结论HLA-B27阳性AS患者中男性居多,且有明显的家族遗传倾向。

Objective To analyze the clinical features of patients with ankylosing spondylitis （AS） and positive human leukocyte antigen-B27 （HLA-B27）. Methods The information of 1 340 patients with AS and positive HLA-B27 including age, sex and heredofamilial history were collected. Erythrocyte sedimentation rate （ESR）, serum rheumatic factor （RF） and levels of human anti-streptolysin O （ASO） were detected. Results The male-to-female ratio was 4. 15 ： 1 in patients with AS and positive HLA-B27. The average age of first diagnosis was 31. 75 and there were 87.31% patients with heredofamilial history. There were 42.5 % patients with ESR over 20 mm/h and 20% patients with ASO over 500 U. Only one patients was with positive RF. Conclusion Patients with AS and positive HLA-B27 are most male and the etiology of AS is related to heredity.