摘要
目的:观察肾癌组织中骨桥蛋白(OPN)的表达并探讨其意义。方法:应用免疫组织化学SP法检测82例肾癌组织及20例肾切除患者正常肾组织中OPN的表达。结果:肾癌组织中OPN阳性表达率为74.39%,明显高于正常肾组织的5.00%,差异具有统计学意义(χ2=32.478,P<0.05)。随肾癌临床分期升高,OPN阳性表达率增加,Ⅰ、Ⅱ期分别为55.00%和66.67%,均低于(Ⅲ+Ⅳ)期的93.75%(χ2=11.182,P<0.05)。OPN在淋巴结转移组的阳性表达率为94.74%,高于无淋巴结转移组的68.25%(χ2=4.074,P<0.05)。结论:OPN的表达与肾癌的浸润转移有关,可作为评价肾癌进展的指标之一。
Aim： To observe the expression of osteopontin（OPN） and study its significance in renal cell carcinoma （ RCC）. Methods：The protein of OPN from 82 patients with RCC and 20 normal renal tissues were detected by immunohistochemistry SP method. Results：OPN protein can be detected in 74.39% （61/82） RCC specimens, and only in 5.00% normal renal tissues, there was significant difference between them （χ2 = 32. 478, P 〈 0.05 ）. The positive rate of OPN ex- pression was 55.00% in clinical stage I and 66.7% in clinical stage II of RCC respectively, which were lower than that of 93.75% in stage（III ＋IV）（χ2 =11.182,P〈0.05）. The positive rate of OPN expression was 94.74% in group with lymph nodes metastasis, higher than that of 68.25% in group without lymph nodes metastasis（χ2 = 4. 074 ,P 〈 0.05 ）. Conclusion ： OPN is related to the invasion and metastasis of RCC, and may be as a marker to evaluate the invasion of RCC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2009年第4期817-819,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
骨桥蛋白
肾癌
osteopontin
renal cell carcinoma
