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乳腺癌组织中Duffy抗原趋化因子受体表达与雌激素受体表达的关系 被引量：3

Duffy Antigen Receptor for Chemokines Expression is Related with ER Expression in Primary Lesion of Breast Cancer
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摘要 目的:探讨乳腺癌组织中Duffy抗原趋化因子受体(DARC)与雌激素受体(ER)表达的关系。方法:中国福利会国际和平妇幼保健院乳腺癌临床组织标本85例,患者年龄28～75(52.68±10.51)岁,通过免疫组化技术检测DARC和ER表达,并对其相关性进行分析。结果:对乳腺癌组织标本的免疫组化检测结果显示:ER阳性表达组DARC阳性和DARC阴性表达分别为29例(69.05%)及13例(30.95%),ER阴性表达组DARC阳性和DARC阴性表达分别为15例(34.88%)及28例(65.12%),ER阳性和ER阴性表达组之间的DARC表达差异具有统计学意义(P<0.01)。DARC表达与ER表达呈正相关(r=0.487,P<0.05)。结论:人乳腺癌组织中Duffy抗原趋化因子受体(DARC)表达与ER有关。 Objective：To analyze the relationship between Dully antigen receptor for chemokines （DARC） and estrogen receptor （ER） expression in human breast cancer. Methods： Human tissue sections were taken from 85 breast cancer patients, 28-75 （52.68 ± 10.51） years old, DARC and ER expression were examined by immunohistochemistry. Results： Showed that positive ER immunostaining was detected in 29 DARC-positive cases（69. 05%） and 13 DARC-negative cases（30.95% ）, respectively. Negative ER immunostaining was detected in 15 DARC-positive cases（34. 88%） and 28 DARC-negative cases（65.12%）, respectively （P〈0.01）, the difference was significant. Conclusion：DARC Expression is related with ER in primary lesion of breast cancer.
作者 王杰 何奇 邵玉国 欧周罗
机构地区 上海交通大学医学院附属国际和平妇幼保健院乳腺科 复旦大学乳腺癌研究所
出处 《中国临床医学》 2009年第4期631-633,共3页 Chinese Journal of Clinical Medicine
基金 上海市卫生局青年课题(2006Y038)
关键词 乳腺肿瘤 雌激素受体 DUFFY抗原趋化因子受体 Breast neoplasms Estrogen receptor Dully antigen receptor for chemokines （DARC）
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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二级参考文献30

  • 1魏思方,王杰,欧周罗,李大强,侯意枫,罗建民,邵志敏.达菲抗原趋化因子受体在不同转移性人乳腺癌细胞中的差异表达[J].复旦学报（医学版）,2005,32(2):139-142. 被引量：1
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共引文献8

同被引文献8

  • 1王杰,欧周罗,侯意枫,罗建民,陈奕,周晋,沈镇宙,丁健,邵志敏.Duffy抗原趋化因子受体抑制人乳腺癌裸鼠移植瘤的生长和肺转移[J].中华医学杂志,2005,85(29):2033-2037. 被引量：7
  • 2欧周罗,王杰,侯意枫,罗建民,沈镇宙,邵志敏.Duffy抗原趋化因子受体参与人乳腺癌的淋巴结转移[J].中华肿瘤杂志,2006,28(8):586-589. 被引量：5
  • 3Sorlie T, Perou CM, Tibshiranie R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [J]. Medical Sci, 2001,98 (19): 10847 10869.
  • 4Wang J, Ou ZL, Hou YF, et al. Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells atten uates growth and metastasis potential[J]. Oncogene, 2006, 25 (54) : 7201-7211.
  • 5Chakera A, Seeber RM, John AE, et aN. The duffy antigen/ receptor for ehemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through het ero-oligomerization [J].Mol Pharmacol, 2008, 73 (5) : 1362- 1370.
  • 6Bandyopadhyay S, Zhan R, Chaudhuri A, et al. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression [J]. Nat Med, 2006, 12(8) 933-938.
  • 7Xing D, Feng W, Miller AP, et al. Estrogen modulates TNF alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor beta aetivation[J]. Am J Physiol Heart Circ Physio,2007, 292(6):2607-2612.
  • 8Kan WH, Hsu JT, Schwacha MG, et al. Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase dependent activation of protein kinase G[J]. Ann Sug,2008, 248(2):294-302.

引证文献3

二级引证文献1

中国临床医学
2009年 第4期

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