甘精胰岛素联合瑞格列奈治疗2型糖尿病38例临床观察

Efficacy of combination therapy with Glargine plus Repaglinide in 38 cases of type-2 diabetes mellitus

目的观察长效胰岛素(甘精胰岛素)联合瑞格列奈治疗2型糖尿病的临床疗效。方法选择我院门诊2型糖尿病患者38例,病程平均5.2年,经口服降糖药或预混胰岛素治疗血糖控制不佳(HbA1c>7.5%)或常发生低血糖,改用甘精胰岛素联合瑞格列奈治疗3个月,观察疗效。结果治疗3个月后患者的空腹血糖、餐后2小时血糖、糖化血红蛋白均有下降(P<0.01)。3例发生轻度低血糖,给予瑞格列奈减量后症状消失,无明显波动。未观察到其他药物副作用,血压、血脂、肝功能、肾功能、心电图等指标较治疗前有不同程度改善。结论甘精胰岛素和瑞格列奈联用是一种较为理想的降糖方法。

Objective To observe the effect of the treatment of Glargine （long-acting insulin） combined with Repaglinide on type-2 diabetes mellitus. Methods Thirty-eight patients with type 2 diabetes mellitus were chosen to be treated by Glargine combined with Repaglinide for three months because their glycemic was controlled badly （HbAlc〉7.5%） or hypoglycemia happened regularly after oral hypoglycemic agents or premixed insulin for a duration of three months to 22 years （average 5.2 years）. Results The FBG, P2hBG, and HbAlc of these patients decreased significantly （P〈0.01）. Hypoglycemia and the side-effects were hardly observed. Their many indicators including blood pressure, blood lipids, liver function, renal function and electrocardiogram were improved significantly. Conclusion The combination of Glargine plus Repaglinide is an ideal therapy for type-2 diabetes mellitus.