腺苷蛋氨酸联合谷胱甘肽治疗慢性乙型肝炎的效果评价

Evaluation of efficacy of glutathione combined with ademetionine in treatment of hepatitis B patients

目的评价腺苷蛋氨酸联合谷胱甘肽治疗慢性乙型肝炎的效果。方法50例慢性乙型肝炎患者随机分为对照组和观察组,对照组采用甘利欣常规治疗,观察组采用腺苷蛋氨酸联合谷胱甘肽治疗。结束后对两组患者的临床效果进行比较。结果观察组临床总有效率为76.00%,高于对照组的临床总有效率48.00%,具有显著差异(χ2=4.1596,P<0.05);观察组治疗后T-BiL为(98.4±15.5)μmol/L、ALT为(86.2±11.6)U/L均低于对照组治疗后的(154.2±11.6)μmol/L、ALT(123.4±16.5)U/L,具有显著差异(P<0.001)。结论腺苷蛋氨酸联合谷胱甘肽治疗慢性乙型肝炎疗效佳,而且也安全,建议临床进一步推广。

Objective To evaluate the effects of glutathione combined with／ ademetionine on chronic hepatitis B patients. Methods There 50 cases with chronic hepatitis B were randomly divided into observation group and control group each with 25 cases,and the control group was treated with diammonium glycyrrihizinate,the observation group was treated with glutathione and ademetionine. Results The effective rate in observation group was 76.00% higher than that of control group （48.00% ,X2 = 4.1596,P〈0.05）. The levels of T-BiL and ALT in observation group after treatment were （98.4 ±15.5 ）p.mol/L and （86.2±11.6）U/L,lower than that of （154.2±11.6）μmol/L and （123.4±16.5）U/L in control group, （P〈0.001）. Conclusions Glutathione combined with ademetionine is effective on chronic hepatitis B patients.