丹参联合补骨胶囊治疗系统性红斑狼疮患者骨质疏松效果

Effect of Salvia miltiorrhiza and Bugu capsule on osteoporosis of systemic lupus erythromatosus patients

目的观察丹参(SM)联合补骨胶囊防治系统性红斑狼疮(SLE)患者长期使用糖皮质激素治疗并发骨质疏松或骨量减少的作用效果。方法90例SLE患者随机分为两组,治疗组(45例)采用糖皮质激素和丹参、补骨胶囊治疗,对照组(45例)采用糖皮质激素治疗,另设健康对照组30例。分析两组患者治疗前后血清生化指标和血甲状旁腺素(Parathyroid hormone,PTH)的变化,并对三角区(Ward’s)等进行了骨质疏松或骨量减少情况测定。结果治疗组治疗前后血生化指标钙、磷、碱性磷酸酶及PTH等的差异无统计学意义(P>0.05),对照组血生化项目中Ca和PTH的表达差异有统计学意义(P<0.01)。治疗组患者骨质疏松或骨量减少的发生率明显低于对照组(P<0.01)。结论丹参联合补骨胶囊可以有效治疗SLE患者骨质疏松或骨量减少,其机制可能是通过调节SLE患者体内血骨钙代谢的平衡紊乱,改善骨髓微环境有关。

Objective To investigate the mechanism of salviam miltiorrhiza combined with Bugu capsules in the treatment of osteoporesis or bone loss in systemic lupus erythematosus （SLE） patients after long-term administration of glucocorticoid. Methods Nity SLE cases were divided into randomly, treatment group consisted of 45 cases and treated with glucocorticoid and salviam miitiorrhiza combined with Bugu capsules and control group consisted of 45 cases and treated with glucocorticoid. All patients were evaluated hy determination of bone mineral density （BMD） and related biochemical parameters such as serum calcium,serum P,serum ALP and serum parathyroid hormone （PTH） before and after treatment. Results The changes of concentrations of serum calcium,serum P,serum ALP and serum PTH before and treatment in treatment group were no significant （P〉0.05）, while in the control group was significant （P〈0.01）. Osteoporosis or bone loss rate in treatment group was significant lower than that of control group （P〈0.01）. Conclusion Salviam miltiorrhiza combined with Bugu capsules is effective in the treatment of osteoporosis and bone loss in SLE patients. The mechanism may involve the regulation of expression of serum calcium and serum PTH and aLso improve the bone marrow microenvironment. Key words：Bugu capsules; Salvia miltiorrhiza; Hormone; Systemic lupus erythematosus; Osteoporosis; Treatment