胃癌患者HSP60的变化情况及与幽门螺杆菌的相关性

Coorelation of level of HSP60 in stomach cancer patients with Helicobacter pylori infection

目的观察胃癌患者热休克蛋白HSP60的变化及与幽门螺杆菌的相关性,以探讨HSP60与幽门螺杆菌感染、胃癌发生之间的关系及其在胃癌发生发展过程中的作用。方法用免疫组织化学技术对HSP60的表达进行定性及半定量测定。结果30例胃癌患者HSP60表达(76.67%)显著高于30例浅表性胃炎患者(30%)(P<0.01)与30例消化性溃疡患者(36.67%)(P<0.01)。与30例萎缩性胃炎患者及不典型增生患者无明显差异(P>0.05)。幽门螺杆菌阳性菌株HSP60表达(55.77%)显著高于幽门螺杆菌阴性菌株(26.09%)(P<0.005)。结论HSP60的过度表达与胃癌、幽门螺杆菌密切相关,HSP60的过度表达可能发生在胃癌发生发展的过程中,从而推断可以通过对HSP60表达的检测,对幽门螺杆菌感染的现状及趋势进行预测,把握胃癌分化的程度的判定,对治疗提供一定的帮助。

Objective To observe the change of HSP60 and its correlation with Helicobacter pylori （HP） in gastric cancer patients. Methods The expression level of hsp60 was determined by immunohistochemistry and image analysis system. Results The expression of HSP 60 of gastric cancer in 30 cases was 76.67% ,much higher than that of 30 supertieial gastxitis cases （30%）（P〈0.01） The expression of HSP60 of positive HP stra/ns （55.77%） was h/gher than that of the negative strains （26.09%） （P〈0.005）. Conclusion The over-expression of HSP60 may occurs during the develomen of gastric cancer.The detection of expression of HSP 60 is of certain assistance diagnosis HP infection and prognosis of gastrict cancer.