慢性荨麻疹与乙型肝炎病毒感染的关系

The relationship between chronic urticaria and hepatitis B virus infection

目的了解慢性荨麻疹与乙型肝炎病毒(HBV)感染的关系。方法检测150例慢性荨麻疹患者(病例组)HBV感染状况,并与100名正常人(对照组)进行比较,分析伴有HBV感染慢性荨麻疹的临床表现特点。结果HBsAg阳性率病例组为19.3%、对照组为10.0%,病例组HBsAg阳性率明显高于对照组(Pearsonχ2=3.970,P<0.05);病例组中HBsAg阳性者与阴性者之间病程、风团大小比较有统计学差异(P<0.05)。结论慢性荨麻疹发病与HBV感染有一定关系,慢性荨麻疹伴有HBV感染者临床上病程较长、风团面积较大。

Objective To investigate the relationship between chronic urticaria and hepatitis B virus （HBV） infection. Methods HBV was tested in 150 patients of chronic urticaria and 100 healthy controls. The clinic features of chronic urticaria patients with HBV were characterized. Results 19.3% of patients with chronic urticaria were positive for HBsAg ,while it was only 10% in control group. HbsAg positive rate in patients with chronic urticaria was significantly higher than that in control group （Pearson X2=3.970,P〈0.05）.There was a significant difference between the patients with HBV and those without HBV in terms of clinical course and area of wheal. Conclusions Chronic urticaria is associated with HBV infection. Patients of chronic urticaria with HBV infection have longer clinical course and larger area of wheal.