期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

新型二氢噻吩并噻吩并嘧啶酮衍生物的合成 被引量：1

Synthesis and properties of new dihydrothienothieno pyrimidinone derivatives
下载PDF
导出
摘要 研究了新型二氢噻吩并噻吩并嘧啶酮衍生物7a～7h的合成方法,该方法应用膦亚胺4与苯基异氰酸酯的氮杂Wittig反应,得到的碳二亚胺5再与仲胺反应,以70%～81%的总产率合成了8种未见文献报道的噻吩并噻吩并嘧啶酮衍生物7a～7h.所得产物7a～7h的结构由NMR,MS,IR和元素分析所确证. Eight unreported dihydro-thienothienopyrimidinones 7a-7h were synthesized in total yields of 70%-81% by a consecutive method, which includes aza-Wittig reaction of iminophospborane 4 with phenyl isocynate to give carbodiimide 5 and subsequent reaction of 5 with various amine. The structure of 7a-7h were confirmed by 1H NMR, MS, IR and elementary analysis.
作者 陈余陆 丁明武
机构地区 华中师范大学农药与化学生物学教育部重点实验室 咸宁职业技术学院生物工程系
出处 《华中师范大学学报（自然科学版）》 CAS CSCD 北大核心 2009年第1期67-69,共3页 Journal of Central China Normal University：Natural Sciences
基金 国家自然科学基金资助项目(20772041)
关键词 二氢噻吩并噻吩并嘧啶酮衍生物 氮杂WITTIG反应 碳二亚胺 膦亚胺 碳二亚胺 dihydrothienothienopyrimidinone thienopyrimidinone aza-Wittig reaction iminophosphorane carbodiimide
分类号 O626.4 [理学—有机化学]
  • 相关文献

参考文献12

  • 1Hozien Z A,Atta F M,Hassan K M,et al.Synthesis and application of some new thienopyrimidine derivatives as antimicrobial agents[J].Synth Commun,1996,26:3733-3755.
  • 2HegdeVB,BisSJ,HeoEC,et al.Preparation of 1,2,4-triazole derivatives as insecticides or acaricides and processes[P].US2002019370,2002.
  • 3Takasugi J J,Buckwaher B L.2-Aryl-delta-1,3,4-(oxa and thia) diazoline insecticidal and acaricidal agents[P].US6235762,2001.
  • 4Ryu E K,Kim H R,Jeon D J.Herbicidal 5-benzyloxymethy1,2-isoxazoline derivatives[P].W00219825,2002.
  • 5Aboulwafa O M,Ismail K A,Koreish,E A,et al.Synthesis and antimicrobial activity of some thiazolinyl tetrahydrobenzo[b]thiopenes and thiazolinyl tetrahydrobenzothiene[-2,3-d]pyrimidin-4-ones[J].Farmaco,1992,47..631-642.
  • 6Fujimoto T T.Method of producing hybrid cereal grain seeds by application of l-aryl-1,4-dihydro-4-oxo (thi)-pyridazines[P].US4345934,1982.
  • 7Wepplo P J,Drabb T W.Process for the preparation of chiral nicotinic,quinolinic or benzoic acid imidazolinone herbicides[P].US6339158,2002.
  • 8丁明武,刘钊杰.氮杂Wittig反应的最近进展[J].有机化学,2001,21(1):1-7. 被引量：36
  • 9伍平凡,胡扬根,丁明武.2-氨基咪唑啉酮衍生物的平行合成[J].华中师范大学学报（自然科学版）,2003,37(2):194-196. 被引量：5
  • 10曾国平,段连生,丁明武.新型四氢吡啶并噻吩并嘧啶-4(3H)-酮衍生物的合成[J].华中师范大学学报（自然科学版）,2008,42(1):58-61. 被引量：6

二级参考文献28

  • 1胡扬根,吕茂云,宋鹤丽,丁明武.2-氨基噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物的合成[J].有机化学,2005,25(3):295-298. 被引量：30
  • 2胡扬根,丁明武.咪唑啉酮类杀菌剂的研究进展[J].华中师范大学学报（自然科学版）,2005,39(4):490-494. 被引量：7
  • 3Lacroix G,Peignier R,Pepin R,et al. Preparation of 2-imidazolin-5-ones and 2-imidazoline-5-thiones as agrochemical fungicides[P]. US 6 002016,1999.
  • 4Okazaki T, Kikuchi K,Watanable T, et al. Studies on nonpeptide angiotensin Ⅱ receptors. Ⅲ. Synthesis and biological evaluation of 5-arylidene-3, 5-dihydron-4H-imidazol-4-one derivatives synthesis, spectral and antimicrobial properties of 5-chloroarylidene aromatic derivatives of imidazolin-4-one [J]. Chem Pharm Bull,1998,46:777-781.
  • 5Kiec-Kononowicz K, Szymanska E, Motyl M, et al. Synthesis, spectral, and antimicrobial properties of 5-chloroarylidene aromatic derivatives of imidazolin-4-one[J]. Pharmazie,1998,53: 680-684.
  • 6Khodair A I,El-Subbagh H I, Al-Obaid A M. Preparation,conformational analysis and antitumor testing for 5-(Z)-arylidene-4-imidazolidinone derivatives [J]. Phosphorus, Sulfur Silicon Relat Elem,1998,140:159-181.
  • 7Ding M W,Xu Z F,Liu Z J,et al. A facile and selective synthesis of 2-alkylamino-4H-imidazolin-4-ones[J]. Synth Commun,2001,31:1 053-1 057.
  • 8Molina P, Pastor A,Vilaplana M J. 6π-electrocyclization of azahex-1,3,5-trienes: A new entry to a regiospecific synthesis of 3-aryl (heteroaryl)pyridines [J]. Tetrahedron, 1993,49 :7 769-7 778.
  • 9Ding M W，Synth Commun，1999年，29卷，1171页
  • 10Ding M W，高等学校化学学报，1998年，19卷，895页

共引文献43

同被引文献17

  • 1胡扬根,吕茂云,宋鹤丽,丁明武.2-氨基噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物的合成[J].有机化学,2005,25(3):295-298. 被引量：30
  • 2TAKASUGI J J, BUCKWALTER B L. 2 - Aryl - del- ta- 1, 3, 4 - (oxa and thia)Diazoline Insecticidal and Acaricidal Agents: US, 6235762[P]. 2001 - 05 - 22.
  • 3HARALD W. Derivatives of Thieno(3,4 - α)pyrimidine and Preparation Thereof: US,3644357[P]. 1972.
  • 4HARALD W, BIRGIT F. Fungicidal Combination Comprising Thieno[2,3 - d] pyrimidine - 4 - one: WO, 0027200[P]. 2000.
  • 5PATIL V D, WISE D S, W L L. Synthesis and Bio- logical Activity of a Novel Adenosine Analog 3 - β - D - Ribofuranosyl Thieno[2,3 - d]pyrimidine- 4 - one[J].J. Med. Chem, 1985, 28. 423- 427.
  • 6HEGDE V B, BIS S J, HHE E C. Preparation of 1,2, 4 - Triazole Derivatives as Insecticides or Acaricides and Processes : US,2002019370[P]. 2002.
  • 7RYU E K, KIM H R, IEON D J. Herbicidal 5 - Benzyloxymethy - 1,2 - isoxazoline Derivatives: WO, 0219825[P]. 2002.
  • 8BRIDES A S, DENNY W A, KRAKER A, et al. Tricyclic Compounds Capable of Inhibiting Tyrosine Kinases of the Epidermal Growth Factor Receptor Family: US, 5679683[P]. 1997.
  • 9TOKIO O, KATSUTOSHI F, ISAMU N, et al. Aminopyrimidine Derivative, Process for Preparing the Dervative and Insecticide or Bactericide Containing the Derivative: EP,0356158[P]. 1989.
  • 10PEINADOR C, OJEA V, QUINTELA J M. A convenient Synthesis for some New Pyrido [ 3 ' 2 ' : 4,5 ] thieno[3,2 - d] pyrimidine Derivatives with Potential Biological Activity[J]. J. Heterocycl. Chem. , 1992, 29: 1963 - 1702.

引证文献1

二级引证文献1

华中师范大学学报（自然科学版）
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部