米非司酮与米索前列醇配伍利凡诺终止中期妊娠300例疗效分析

Mifepristone and Misoprostol Combination Rivanol Trimester Termination of the Clinical Analysis of 300 Cases

目的探讨米非司酮与米索前列醇配伍利凡诺终止中期妊娠的临床疗效。方法对300例要求终止中期妊娠的孕妇(观察组)在羊膜腔内注射利凡诺的同时,口服米非司酮75 mg,宫缩发动时给予阴道后穹窿米索前列醇0.2 mg。另选同期单纯行利凡诺羊膜腔内注射引产的孕妇300例为对照组。比较2组的宫缩产程、出血量、引产成功率及胎盘残留情况。结果观察组的宫缩发动时间、胎儿胎盘娩出时间、产后出血量及胎盘残留发生率均明显低于对照组(均P<0.05),引产成功率高于对照组(P<0.05)。结论米非司酮与米索前列醇配伍利凡诺用于终止中期妊娠,明显缩短引产时间及产程,减少产后出血量及胎盘残留的发生。

Objective To analyze the clinical effects of mifepristone and misoprostol in terminating medium-term pregnancy when combined with rivanol. Methods Three hundred cases of medium-term termination of pregnancy,were injected rivanol into amniotic cavity, and took mifepristone orally and put misoprostol into posterior fornix before uterine contraction （observation group）. Over the same period, 300 cases induced abortion only by injection of rivanol into amniotic cavity（control group）. Birth process, achievement ratio of induced abortion and placental adhesion were compared in two groups. Results The placental delivery time,amount of bleeding and placental adhesion incidence of the observation group were significantly lower than that of control group（P〈0.05）, but the achievement ratio of induced abortion was higher than that of control group（P〈0.05）. Conclusion The combination of mifepristone and misoprostol with rivanol for termination of medium-term pregnancy can significantly shorten time of induced abortion,reduce the amount of postpartum hemorrhage and the incidence of placenta adhesion.