氨茶碱和盐酸纳洛酮的配伍稳定性研究

Stability of Aminophylline Injection and Naloxone Hydrochloride Injection in Compatibility Solutions

目的考察氨茶碱注射液与盐酸纳洛酮注射液的配伍稳定性。方法将2种注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后,于室温放置8h,观察外观,测定pH及不溶性微粒的变化情况,并采用高效液相色谱法测定配伍液的含量。结果室温8h内,氨茶碱与纳洛酮在0.9%氯化钠注射液和5%葡萄糖注射液中的外观、pH、微粒及含量均无明显变化。结论氨茶碱注射液与纳洛酮注射液配伍,以0.9%氯化钠注射液和5%葡萄糖注射液作为溶剂,在8h内稳定。

Objective To study the compatible stability of Aminophylline Injection and Naloxone Hydrochloride Injection. Methods The changes in appearance, particles and pH value of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection within 8 h at ambient temperature were observed. The concentrations of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection were determined by HPLC- UV within 8 h. Results Within 8 h at room temperature, no obvious changes in the pH value, particle number and contents of both drugs in 0. 9% sodium chloride injection and 5% glucose injection were demonstrated. Conclusion Aminophylline Injection was shown to be compatible with Naloxone Hydrochloride Injection in 0.9% sodium chloride injection and 5% glucose injection within 8h.