急性冠脉综合征患者血清hs-CRP和sCD40L临床特点

The Clinical Significance of Serum hs-CRP and sCD40L Levels in Patients with Acute Coronary Syndrome

目的观察急性冠状动脉综合征(ACS)患者血清超敏C反应蛋白(hs-CRP)和可溶性CD40配体(sCD40L)的变化及临床意义。方法采用夹心法酶联免疫吸附测定分析(ELISA)及微粒子增强透射免疫分析法分别测定对照组、稳定型心绞痛(SAP)组、ACS组的血清sCD40L和hs-CRP水平,并观察经皮冠状动脉介入(PC I)术对其的影响。结果①ACS组血清hs-CRP及sCD40L水平均高于SAP及对照组(P<0.01),SAP组与对照组无统计学差异(P>0.05);②相关分析显示血清sCD40L水平与hs-CRP呈正相关(r=0.787,P<0.001);③SAP和ACS组PC I术后血清hs-CRP、sCD40L水平均较术前显著升高(P<0.01)。结论ACS组患者血清hs-CRP、sCD40L水平显著增高,提示冠心病的不稳定状态,可能有助于临床识别和预测ACS。

Objective To observe the clinical significance of serum high-sensitive C-reactive protein （hs-CRP） and soluble CIM0 ligand（sCIMOL） levels in patients with acute coronary syndrome（ACS）. Methods 49 patients with ACS, 27 patients with SAP,and 15 controls entered this study. The serum levels of sCIMOL and hs-CRP were measured by enzyme linked immunosorbent assay（ELISA） and particle-enhanced immunon- ephelomerty respectively. Results （1） The serum levels of hs-CRP and sCIMOL were higher in ACS group than those of SAP group and control group （P 〈 0.01 ）, while no significant difference was found between SAP group and control group （ P 〉 0.05）. （2） The serum level of hs-CRP was significantly correlated with that of sCIMOL（ R =0. 787 ,P 〈0.001 ）. （3） In both ACS group and SAP group, the levels of hs-CRP and sCIMOL after percutaneous transluminal coronary intervention （PCI） were elevated significantly compared with those before PCI （ P 〈 0.01 ）. Conclusion Significant increase of serum hs-CRP and sCIMOL levels suggestes the unstable condition of coronary heart disease, and might be considered suitable markers for identifying and predicting ACS.