宫颈癌及宫颈上皮不典型增生组织中ER、PR的表达及其意义

Expression and Significance of ER,PR in Tissues of Cervical Cancerand Cervical Intraepithelial Neoplasia

目的探讨ER、PR表达水平与宫颈癌各项临床病理指标、组织分化的关系及其意义。方法用免疫组化方法对60例宫颈癌、41例宫颈上皮不典型增生(C IN)及40例慢性宫颈炎组织的石蜡标本进行ER、PR检测。结果ER、PR在慢性宫颈炎组、C IN组及宫颈癌组中的表达逐渐减低,其差异有统计学意义(P<0.05);随着临床分期及肿瘤细胞病理分级的提高,ER、PR水平呈下降趋势,但差异无显著性意义(P>0.05),ER、PR与临床分期、肿瘤细胞病理分级关系不明;宫颈癌组绝经前的ER、PR阳性率虽然均高于绝经后,但差异无统计学意义(P>0.05)。结论雌、孕激素及其受体可能在宫颈癌的发生、发展中起一定的作用,对宫颈癌或C IN患者进行ER、PR检测有助于指导治疗及预后。

Objective To study the expression of ER, PR in tissues of cervical cancer and cervical intra- epithelial neoplasia（CIN） and its relationship with various clinic pathological factors and tissue differentiation. Rethods The expression of ER and PR in 60 cases of uterine cervix cancer,41 cases of CIN and 40 cases of chronic cervicitis was detected by immunochemistry. Results The expression of ER, and PR was gradually re- duced in chronic cervicitis, CIN and uterine cervix cancer, and the difference was significant among them（ P 〈 0.05）. The expression of ER and PR was gradually reduce with the elevation of clinical stage and pathological grade of tumor, but the difference was not signicicant （ P 〉 0.05 ）. Conclusion Estrogen and Progesterone, ER and PR may play a certain role in the development of uterine cervix cancer, and the detection of ER and PR in uterine cervix cancer and CIN may help for estimating prognosis and instructing therapy.