肿瘤标记物联合检测对胰腺癌的诊断价值

Role of Combined Detection of Serum Tumor Markers in Diagnosis of Pancreatic Cancer

目的探讨糖类抗原CA199、CA242及CEA联合检测对胰腺癌患者的临床诊断价值。方法用放射免疫分析法检测胰腺癌病人55例、良性胰腺疾病49例、正常对照61例的CA199、CA242及CEA血清水平。结果胰腺癌患者血清CA199、CA242及CEA值均明显高于正常组及良性胰腺疾病组,两者比较有显著性差异(P<0.05);CA199、CA242及CEA联合检测较单测任何一项其灵敏度、特异度均有提高,分别达到87.3%和89.1%。结论胰腺癌肿瘤标志物CA199、CA242及CEA可作为早期诊断胰腺癌的工具,联检CA199、CA242及CEA能提高对胰腺癌的诊断和鉴别诊断效率。

Objective To investigate the clinical value of combined test of serum CA199, CA2A2 and CEA levels in the diagnosis of patients with pancreatic cancer. Methods Serum levels of CA199, CA242 and CEA in 55 cases of pancreatic cancer patients, 49 cases of benign pancreatic lesion patients and 61 normal con- trois were detected by radioimmunoassay. Results Serum CA199 , CA242 and CEA levels in pancreatic cancer patients were significantly higher than those in normal controls and benign pancreatic lesion patients （P 〈 0. 05 ）. If serum CA199 , CA242 and CEA were detected simultaneously, the sensitivity and specificity of diagno- sis of pancreatic cancer could be improved, and reached 87.3% and 89.1% respectively. Conclusion The changes of serum CA199, CA242 and CEA levels are helpful in the diagnose of pancreatic cancer. The com- bined detection of serum CA199, CA242 and CEA could improve the sensitivity and specificity in diagonosis and differential diagnosis of pancreatic cancer.