高白细胞性急性白血病50例临床研究

Clincal study on 50 patients witlI hyperleukocytic acute leukemia

目的探讨高白细胞性急性白血病(HAL)的临床特征、治疗效果及预后分析。方法对50例HAL进行临床回顾性分析,同时以100例非高白细胞性急性白血病(NHAL)作对照组。结果HAL症状重;HAL治疗有效率为58.0%,低于NHAL的76.0%;HAL组早期病死率是22.0%,高于对照组的9.0%,有统计学差异。结论HAL治疗有效率低,早期病死率高,预后差,应化疗前行白细胞单采术有效降低白细胞数,再给予足量、规范的联合化疗,预防各种并发症,才能有效地提高临床疗效,降低病死率。

Objective To investigate the clinical Characteristi - cs, therapeutic effects and the prognostic factors of patients with hyperleukocytic acute leukemia （ HAL）. Methods Reviewed 50 patients with acute leukemia characterized with hyperleukoeyto - sis and 100 cases of nonhyperleukocytic acute leukemia（NHAL）. Results The symptom of HAL was heavier than NHAL. After treatment, the effective ratio of HAL,which was 58.0% , was lower than that of NHAL,which was 76.0% . The early mortality rate of HAL, which was 22.0% , was higher than that of NHAL, which was 9.0%. There was significant difference （ P 〈 0.05 ）. Conclusion HAL patients have poor prognosis, low effective ratio of threatment and high early mortality rate.