东莞市孕产妇血铅锌对孕产妇、胎儿和新生儿发育的影响

A research of effection of pregnancy lying-in woman blood lead zinc over the pregnancy lying-in woman

目的观察不同孕期孕妇血液及脐血中铅锌水平与不同的妊娠结局及新生儿发育的关系,了解东莞地区的孕产妇的铅污染及锌缺乏程度,判断是否需常规筛查铅锌的水平,用以指导孕产妇优生优育。方法选取早孕期位于2005年5月至2007年12月并在医院分娩的孕产妇500例及其新生儿,进行静脉血和脐带血铅及其他微量元素的分析检测,并采用新生儿20项行为神经测定法进行新生儿神经系统的评分。结果产妇血铅与新生儿脐血铅含量呈正相关。铅锌含量异常均对新生儿的神经系统发育产生影响。结论铅锌对胎儿的神经发育有明显影响,但铅锌的致畸作用在本次实验中尚不能明确体现,有待进一步的研究证实。

Objective To monitor the relationship between blood levels of lead and zinc in pregnant women and naval blood with outcome of pregnancy and development of neonates. To realize the degree of contamination of lead and degree of shortage of zinc in pregnant and lying - in women in Donggnan area in order to guide a good birth and good care in pregnancy and lying - in women. Methods Monitoring and analysis of blood levels of lead and other mieroelements in women with early pregnancy, lying -in women and their newborn babies and their umbilical cord were carried out during May 2005 to December 2007. The evaluation of nervous system of these neonates was scored with Neonatal Behavioral Neurological Assessment. Results Blood level of lead in lying - in women was positively correlated to lead contents in naval blood of newborn babies. Abnormal contents of lead and zinc both had influence on development of nervous system in neonates. Conclusion Lead - zinc had obvious effect on neural development of fetus, but the teratogenic effect of lead and zinc still could not make clear in this study and it needs further studies.