左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床研究

Clinical investigation on the effect of levonorgestrel-releasing intrauterine system on adenomyosis

目的:探讨左炔诺孕酮宫内缓释系统LNG-IUS治疗子宫腺肌病的临床疗效。方法:选择94例子宫腺肌病患者宫内放置LNG-IUS,观察其放置前后月经量、痛经程度、血红蛋白水平及子宫体积变化。结果:放置LNG-IUS1个月后月经量减少至放置前的(32±11)%,3月后减少至放置前的(24±8)%,12个月后减少至放置前的(6±3)%,各月月经量放置前后比较差异有统计学意义(P<0.01);子宫体积在治疗后与治疗前比较,差异无统计学意义(P>0.05);患者痛经症状显著缓解或完全消失;37例贫血患者血红蛋白水平从治疗前的(89±12)g/L恢复至治疗后的(126±10)g/L。结论:LNG-IUS治疗子宫腺肌病有较好的疗效。

Objective： To explore the clinical efficacy of levonorgestrel -releasing intrauterine system （LNG -IUS） in the treatment of adenomyosis. Methods： 94 cases with adenomyosis were treated with LNG - IUS, and the menstrual blood volume, degree of dysmenorrheal, hemoglobin level and uterine volume were observed. Results： After one month, 3 months and 12 months, the menstrual blood volume reduced to （ 32 ± 11 ） %, （24 ± 8 ） % and （ 6 ± 3 ） % of those before treatment, respectively, there was significant difference in menstrual blood volume before and after the treatment （P 〈 0. 01 ） ; there was no signifieant difference in uterine volume before and after the treatment （ P 〉 0. 05 ） ; dysmenorrheal relieved obviously or completely ; hemoglobin level recovered from （ 89 ± 12） g/L to （ 126 ± 10 ） g/L in 37 patients with anemia. Conclusion ： LNG - IUS is an effective method in the treatment of adenomyosis.