参芪扶正注射液在胃癌腹腔温热灌注化疗中的应用

Application of Shenqi Fuzheng injection （SQFZI） on hyperthermic intraperitoneal lavage chemotherapy for gastric cancer

目的探讨参芪扶正注射液在胃癌患者腹腔温热灌注化疗中的作用。方法将60例进行术后腹腔温热灌注化疗的胃癌患者分为两组，实验组加用参芪扶正注射液。观察治疗期间出现的不良反应及终止腹腔化疗的例数，治疗前、后检查外周血WBC、Hb、PLT及T淋巴细胞亚群（CD4、CD8、CD4／CD8）的变化。结果实验组的不良反应的发生率及终止腹腔化疗的例数明显少于对照组，有统计学差异（P〈0．05）。实验组的WBC计数下降明显低于对照组，差异有显著性（P〈0．05）。实验组CD4、CD4／CD8明显提高，与对照组比较差异有显著性（P〈0．05）。结论胃癌术后腹腔温热灌注化疗合并应用参芪扶正注射液可明显改善免疫功能，防止白细胞下降，帮助肿瘤患者顺利完成治疗，最终提高患者生活质量。

Objective To discuss the effect of Shenqi Fuzheng injection（ SQFZI） on hyperthermic intraperitoneal lavage chemotherapy for gastric cancer. Methods Sixty gastric cancer patients were assigned to two groups randomly,the control group treated with hyperthermic intraperitoneal lavage chemotherapy alone and the treated group treated with SQFZI combined with hyperthermic intraperitoneal lavage chemotherapy. To observe incidence rate of untoward reaction and the cases of stoping hyperthermic intraperitoneal lavage chemotherapy. To detect the changing of WBC, Hb, PLT and subsets of lymphocytes （ CD4, CD8, CD4/CD8 ） in peripheral lymphocytes counts before and after treatment. Results Incidence rate of untoward reaction and the cases of stoping hyperthermic intraperitoneal lavage chemotherapy in treated group were significantly lower than that in control group （P 〈 0.05）. There were statistical differences between treated group and control group. The descent of WBC in treated group were significantly lower than that in control group （ P 〈 0. 05 ）. There were statistical differences between treated group and control group. The percentage of CD4 and the number of CD4/CD8 in treated group were significantly higher than that in control group（ P 〈 0.05 ）. There were statistical differences between treated group and control group. Conclusions SQFZI could effectively improve the immune function, prevent the descent of WBC of gastric carcinoma patient treated with hyperthermic intraperitoneal lavage chemotherapy, help gastric carcinoma patient to finish their treatment ,raise patients＇quality of life.