代谢综合征中医分型及与过氧化物酶体增殖物激活受体-γ的关系

The Patterns of Metabolic Syndrome in TCM and its Relationship with PPAR-γ

目的探讨代谢综合征（Metabolic syndrome，Ms）中医分型及其与过氧化物酶体增殖物激活受体-γ（PPAR-γ）的关系。方法选取2007—06—2007—10期间在广东省中医院住院的MS患者83例，综合中医四诊资料，对其进行辨证分型，分为痰湿内阻、气阴两虚、阴阳两虚、淤血内停4个基本证型，分析MS中医各证型的发生率及其与PPAR-γ的关系。结果MS中医证型以痰湿内阻型居多，其次为气阴两虚及淤血内停型，阴阳两虚型最少。（PPAR-γ）在各证型中表达具有明显差异（P〈0．05），其顺序依次为痰湿内阻型〉瘀血内停型〉气阴两虚型〉阴阳两虚型。结论痰湿内阻型在MS申最为常见，PPAR-γ在痰湿内阻型的表达明显高于其余各证型。

Objective To investigate the patterns of metabolic syndrome in TCM and its relationship with PPAR - γ. Methods 83 patients who were treated in Guangdong provincial traditional Chinese medicine hospital from June to October in 2007 were included in this study. According to the materials from the patietints and the thoughts of the traditional Chinese medicine, we divided the patients into four basic TCM patterns, namely,＂ qi＂ and ＂fin ＂deficit syndrome, retention of phlegm syndrome, blood stasis syndrome and yin and yang deficit syndrome. To compare the distribution of different patterns and the relationship with PPAR -γ. Results The distribution of the four patterns in MS patients were qi and yin deficit syndrome 27%, retention of phlegm syndrome36%, blood stasis syndrome 25%, ＂yin ＂and ＂yang＂ deficit syndrome 12%. There was dramatically difference of PPAR - γ among different patterns （P 〈 0.05）. Conelusion Retention of phlegm syndrome is the most popular pattern of MS, and the PPAR - γ level of retention of phlegm syndrome is higher than that of the other patterns.