摘要
以4-反式-正丙基环己基甲酸(Ⅰ)为原料,经过LiAlH4的还原,得到4-反式-正丙基环己基甲醇(Ⅱ),再经过溴代反应,合成了4-反式-正丙基环己基溴代甲烷(Ⅲ),此溴代物制备成格氏试剂与CO2气体反应得到目标化合物4-反式-正丙基环己基乙酸(Ⅳ),总产率47.9%。并对产物用GC-MS,1HNMR进行了表征。此种方法较文献上普遍采用的合成方法有了较大的改进,提高收率、降低成本,并且避免了KCN、NaCN这样的剧毒物的使用。
4 - Trans - （ n - propyl） cyclohexyl acid（ Ⅰ） was reducted with LiAlH4 to pruduce the 4 - trans - （ n -propyl） cyclohexyl methanol（ Ⅱ ）. The compound Ⅱ was bromized to produce the 4 -trans - （n -propyl）cyclohexyl bromic methane（ Ⅲ ）. And then the goal product 4 - trans - （ n - propyl） eyclohexyl acetic acid（ Ⅳ ） was abtained from treatment of Grignard rengent from compound m with carbon dioxidein overall yield of 47.9%. And the structure of the goal compound are characterized by means of GC - MS, ^1HNMR. This method has more advantageous than synthesis method by mentioned in the past literature such as increasing yield, decreasing cost, nontoxicity.
出处
《化工时刊》
CAS
2009年第8期30-31,51,共3页
Chemical Industry Times
关键词
丙基环己基甲酸
丙基环己基甲醇
还原
格氏试剂
丙基环己基乙酸
合成
4 - trans - （ n - propyl） cyclohexyl acid 4 - trans - （ n - propyl） cyclohexyl methanol reduction -ri / -J - - JGrignard reagent 4 - trans - （n - propyl） eyelohexyl acetic acid sythesis
