膀胱黏膜增生性病变与人乳头瘤病毒(HPV)16/18型感染的相关性研究

Relation between bladder mucous hyperplasia and human papillomavirus(HPV)16/18 infection

目的探讨膀胱黏膜增生性病变的病原机制,研究与人乳头瘤病毒16/18感染的相关性。方法随机选取慢型性膀胱炎32例、膀胱黏膜增生性病变43例的组织标本,采用聚合酶链反应(PCR)法检测组织中HPV16/18的感染阳性率,进行统计学分析。结果HPV16/18型感染率慢性膀胱炎组为71.88%,膀胱黏膜增生性病变组81.40%(其中腺性膀胱炎78.57%,瘤样增生100%,上皮鳞化80%,腺性膀胱炎伴上皮鳞化85.71%),两组间感染率差异无统计学意义。结论膀胱黏膜上皮的HPV16/18感染可能是膀胱黏膜增生性病变的重要致病因素。膀胱黏膜HPV16/18感染可能在慢性膀胱炎→增生型膀胱炎→膀胱癌的发生和发展过程中起着重要作用。

Objective To research the etiology of bladder mucous hyperplasia, and to explore the relation between bladder mucous hyperplasia and human papillomavirus （HPV） 16/18 infection. Methods Seventy-five randomized selective specimens of chronic cystitis and bladder mucous hyperplasia were detected by polymerase chain reaction（PCR） to confirm the infective rate of HPV16/18. Results The infective rates of HPV16/18 were 71.88% in chronic cystitis,81.40% in bladder mucous hyperplasia（glandular cystitis 78.57%, papillomatous hyperplasia 100%, squamous metaplasia 80%, glandular cystitis accompanying squamous metaplasia 85.71% ）. There was no significant difference between the HPV16/18 infective rates of chronic cystitis and bladder mucous hyperplasia. Conclusion The infection of HPV16/18 may be an important etiological factor of bladder mucous hyperplasia. The infection of HPV16/18 may be a vital event in the progressive course of chronic cystitis→bladder mucous hyperplasia→bladder transtional cell carcinoma（BTCC）.