50-59岁女性冠脉造影特点及冠心病危险因素分析

Analysis on the Characteristics of Coronary Heart Disease in 50 - 59 Years Old Women Angiography and the Risk Factors of Coronary

【目的】探讨50～59岁女性疑诊冠心病患者的冠脉造影特点和危险因素。【方法】选择2004年6月至2007年12月疑诊为冠心病而住院的50～59岁女性患者170例，根据冠状动脉造影结果分为冠心病组（60例）和非冠心病组（110例），分析冠心病组的冠状动脉病变特点及危险因素。【结果】两组间年龄、吸烟史、高血压、体重指数差异均无统计学意义（P〉0．05）。合并糖尿病、高脂血症的比例分别为38％比7％、42％比24％，两组间差异显著（P〈0．05）。两组间血糖、低密度脂蛋白水平差异显著（P〈0．05）。冠心病组冠脉单支病变、双支病变、多支病变比例分别为12％、35％、53％；轻度狭窄、中度狭窄、重度狭窄比例分别为35％、45％、20％。10gistic回归提示糖尿病及血脂异常是冠心病的独立危险因素。【结论】糖尿病及高脂血症是引起50～59岁女性冠心病发病的独立危险因素；50～59岁女性冠心病患者的造影特点以多支病变，血管中度狭窄为主。

[Objective] To explore the characteristics of coronary angiography and risk factors of suspected coronary artery disease（CAD） in 50-59 years old female patients. [Methods]A total 170 female patients of 50 -59 years old suspected of CAD were admitted from June 2004 to December 2007. According to coronary angiography result, the patients were divided into CAD group （ n = 60） and normal group（ n = 110）. The characteristics of coronary angiography and risk factors in CAD group were retrospectively analyzed. [Results] The age, smoking, hypertension and BMI were similar between two groups（ P〉0.05）. The incidefice of diabetes （38%） and hyperlipoidemia（42%） in CAD group were significantly higher than those（7% and 24%） in normal group（ P〈0.05）. In CAD group, the rate of single vessel lesion, double vessel lesion and multivessel lesion were 12 %, 35% and 53 %, and the rate of light vessel stenosis, midrange vessel stenosis and serious vessel stenosis were 35%, 45% and 20%, respectively. The logistic regression results showed that diabetes and hyperlipoidemia were important independent risk factors for the development of CAD. [Conclusion]Diabetes and hyperlipoidemia are important independent risk factors for the development of CAD in 50-59 years old women. Multi-vessel lesion and midrange vessel stenosis are the major characteristics in this special CAD group.