摘要
目的:研究胃癌DNA微小卫星体不稳定性(MIN)及其与胃癌临床病理特点的关系。方法:采用放射性同位素PCR为基础的RER测定方法,对106例系列胃癌进行研究。结果:RER阳性在膨胀性生长方式胃癌中的表达明显高于在浸润性生长方式胃癌中的表达(P<0.005),而RER阳性与胃癌组织学类型,pTNM分期以及年龄和性别无明显关系(P>0.05)。结论:提示MIN在相当一部分胃癌,尤其在被公认为愈后良好的膨胀性生长方式胃癌的发生。
Objective:To study the relationship between microsatellite instability (MIN) and clinico pathologic characteristics of gastric cancer (GC).Method: MIN was examined in a series of 106 cases of GC using radioactive PCR based technique of RER (Replication error) analysis. Results: The frequency of MIN was significantly higher in expanding type of GC as compared with the infiltrative type of GC ( P <0.005). No significant association with histologic type, pTNM stage,age and sex were found in our study ( P <0.05). Conclusion: These findings indicate that MIN might be an important contributor to the development of a significant number of GC which generally has a better prognosis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第8期561-564,共4页
Chinese Journal of Clinical Oncology
关键词
微小卫星体
不稳定性
胃肿瘤
病理特点
DNA
Microsatellite Instability Stomach neoplasm Clinico pathologic characteristics