胃癌DNA微小卫星体不稳定性研究及其与胃癌临床病理特点的关系

The Relationship between DNA Microsatellite Instability and Clinico pathologic Characteristics of Gastric Cancer

目的：研究胃癌ＤＮＡ微小卫星体不稳定性（ＭＩＮ）及其与胃癌临床病理特点的关系。方法：采用放射性同位素ＰＣＲ为基础的ＲＥＲ测定方法，对１０６例系列胃癌进行研究。结果：ＲＥＲ阳性在膨胀性生长方式胃癌中的表达明显高于在浸润性生长方式胃癌中的表达（Ｐ＜０．００５），而ＲＥＲ阳性与胃癌组织学类型，ｐＴＮＭ分期以及年龄和性别无明显关系（Ｐ＞０．０５）。结论：提示ＭＩＮ在相当一部分胃癌，尤其在被公认为愈后良好的膨胀性生长方式胃癌的发生。

Objective:To study the relationship between microsatellite instability (MIN) and clinico pathologic characteristics of gastric cancer (GC).Method: MIN was examined in a series of 106 cases of GC using radioactive PCR based technique of RER (Replication error) analysis. Results: The frequency of MIN was significantly higher in expanding type of GC as compared with the infiltrative type of GC ( P <0.005). No significant association with histologic type, pTNM stage,age and sex were found in our study ( P <0.05). Conclusion: These findings indicate that MIN might be an important contributor to the development of a significant number of GC which generally has a better prognosis.