摘要
目的:研究食管癌中P-糖蛋白表达的意义。方法:采用免疫组化方法检测52例食管癌、9例鳞状上皮不典型增生及26例正常食管组织中P-糖蛋白的表达。结果:60%的食管癌、33%的不典型增生及12%正常食管组织中均有阳性表达。食管癌中P-糖蛋白表达与组织类型相关。结论:P-糖蛋白的表达参与了食管癌天然性耐药的产生。
A series of 52 esophageal carcinomas,9 dysplasia and 26 normal esophageal mucosa samples was studied immunohistochemically to determine the expression of P glycoprotein. The positive expression was found in 60% of esophageal carcinomas, 33% of dysplasia and 12% of normal mucosa.The results suggest that P glycoprotein may participate the intrinsic resistance.It may contribute to better chemotherapeutic effect for esophageal carcinoma
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第8期588-590,共3页
Chinese Journal of Clinical Oncology
关键词
食管肿瘤
P-糖蛋白
病理
P glycoprotein Esophageal carcinoma Multidrug resistance