5517例药源性肾损害中文文献分析

Analysis of 5517 cases of drug-induced kidney damage on Chinese literatures

目的:探讨引起肾损害的药物分布及一般规律。方法:通过CNKI-CHKD对1994～2007年国内医药期刊报道的药源性肾损害病例进行统计分析。结果:5517例药源性肾损害不良反应涉及155种药物,其中以利尿脱水药、抗微生物药物为主,位居首位的是甘露醇,共2314例(41.94%),其次为头孢拉定886例(16.06%)。结论:临床工作者应掌握引起药源性肾损害的药物分布特点及一般规律,以达到安全用药。

Objective： To investigate disposition and general rule about the drugs which can result in kidney hartnfulness. Methods： The documents about the drug-induced kidney harmfulness on internal medicine periodical from 1994 to 2007 by applying CNKI-CHKD were statistically analyzed. Results： Adverse reactions caused by the 5 517 examples of drug- induced kidney damage involves in 155 kinds of drugs. Among the total, most of the drugs were Emictory and Antimicrobial drugs. The primary one was Mannitol, which resulted in 2 314 cases （41.94%）, followed by 886 cases of Cefradine（16.16%）. Conclusion： Clinical worker should handle the disposition and general rule about the drug-induced kidney harmfulness, in order to safely apply medicine.