(硫杂)杯[4]芳烃缩氨基(硫)脲(桥联)衍生物的合成

Syntheses of (Thia)calix[4]arene (Thio)semicarbazone(-bridged) Derivatives

对叔丁基(硫杂)杯[4]芳烃-1,3-二醛基衍生物4a和4b与苯基氨基硫脲进行"1+2"缩合反应,合成了杯[4]芳烃缩氨基硫脲衍生物5a和5b,产率为84%和85%.化合物4a和4b与1,6-己基双氨基脲发生"1+1"缩合反应,合成了杯[4]芳烃双缩氨基脲桥联衍生物6a和6b,产率为83%和80%.新化合物的结构与构象经元素分析、质谱、核磁共振谱等表征证实.

（Thia）calix[4]arene thiosemicarbazone derivatives 5a and 5b were synthesized by ＂1 ＋2＂ condensation of 1,3-bis[2-（p-formylphenyloxy）ethyloxy]-p-tert-butylcalix[4]arene 4a and 4b with 1-phenylthiosemicarbazide in yields of 84% and 85%, respectively. （Thia）calix[4]arene semicarbazone-bridged derivatives 6a and 6b were prepared by reacting compounds 4a and 4b with 1,6-hexylenebis（1-semicarbazide） in ＂1 ＋ 1＂ condensation in yields of 83% and 80%, respectively. The structures and conformations of the new compounds were characterized by elemental analyses, ESI-MS, 1H NMR, etc.