单侧海马结构损伤患者特征-整合工作记忆的行为学分析

Behavioral analysis by association working memory tasks of the human with half hippocampal formation lesion

目的探讨单侧海马结构损伤患者在工作记忆时分别记忆颜色、空间及颜色-空间整合时的认知行为特点。方法13例单侧海马结构损伤患者和13名年龄、性别及文化程度相匹配的健康对照者分别从事颜色、位置和颜色-位置整合三种工作记忆延迟匹配样本任务，计算机记录其行为反应时间和正确率，并统计学分析。结果海马结构损伤组在颜色记忆或空间记忆任务时的行为反应时间[（1167．46±99．52）ms；（915．85±46．19）ms]和正确率[（79．23±2．42）％；（81．77±2．55）％]较对照组[（1132．61±97．90）ms，（80．69±1．55）％；（888．77±65．94）ms，（83．69±2．63）％]差异均无统计学意义（P〉0．05）；颜色-空间整合记忆时其反应时间[（1146．69±51．93）ms]长于健康对照组[（1073．08±51．42）ms]，而反应正确率[（73．92±2．87）％]却较对照组[（83．92±2．72）％]明显下降，且差异均有统计学意义（P〈0．05）。结论海马结构在视觉-空间整合的工作记忆中起重要作用。

Objective To investigate the behavioral characteristic of the human with half hippocampal formation lesion engaged in color task, location task and color-location associated task of working memory. Methods The behavioral performances were recorded from 13 patients of half hippocampal formation lesion and 13 healthy subjects while performing three binding tasks. A t-test was adopted. Results In color task or location task, behavioral performances of reactiou time [ （ 1167.46±99.52 ） ms; （915. 85±46. 19） ms] and accuracy [ （79.23±2.42） % ; （81. 77±2. 55 ） %] of patients had no statistical significance of the healthy subjects [（1132.61±97.90）ms,（80.69±1.55）% ;（888.77±65.94 ）ms,（83.69±2.63）% l. But that in associated task of patients were statistical significant worse. In eolor-locatiou task, the reaction time[ （ 1146.69±51.93 ） ms] of patients is longer than that of the healthy subjects [ （ 1073.08±51.42 ） ms ] , and the reaction accuracy [ （ 73.92±2.87） % ] of patients was worse than that of healthy subjects [ （ 83.92±2.72 ） % 1. Conclusion The hippocampal formation plays a significant role for working memory of simple visuo-spatial associations.