三种神经肽在活动期溃疡性结肠炎中的表达及意义

Expressions of three neuropeptides in active ulcerative colitis

目的研究三种神经肽在溃疡性结肠炎(UC)及正常结肠黏膜中的差异表达变化及意义。方法运用免疫组织化学方法测定血管活性肠肽(VIP)、P物质(SP)和生长抑素(SS)在43例溃疡性结肠炎及13例正常结肠黏膜中的表达。结果UC中VIP和SS较正常组织表达下降,而SP表达较正常组织增加。结论VIP、SP及SS参与UC的发病过程,且与腹泻的次数存在一定关联性。

Objective To investigate the expression and significance of neuropeptide in ulcerative colitis （UC） and normal mucocus. Methods Immunohistochemistry method was used to detect the expression of vasoactive intestinal polypeptide （VIP）, substance P （SP） and somatostatin （SS） in 43 cases of UC and 13 cases of normal mucocus. Results VIP and SS were lower in UC patients than those in controls, while SP was higher in UC patients. Conclusion VIP, SP and SS take part in the pathogenesis of UC and relate to the number of times of diarrhea.