转化生长因子-β_1与支气管哮喘患者呼吸道重塑的关系研究进展

Study Progress on Relationship of Transforming Growth Factor-β_1 and Airway Remodelig in Asthma

支气管哮喘的发病过程中,转化生长因子β1(TGF-β1)起重要作用。其可刺激成纤维细胞生长,是致纤维化的重要细胞因子,可引起哮喘患者呼吸道重塑。目前研究认为TGF-β1与呼吸道重塑密切相关。与TGF-β1相关的哮喘呼吸道重塑的干预方法可能在哮喘的诊治方面取得突破。糖皮质激素(如地塞米松、布地奈德等)可在一定程度上对呼吸道重塑产生影响。另外,干扰素-γ,部分中医药如川芎嗪、雷公藤、银杏叶等可能通过干预TGF-β1的表达来干预呼吸道重塑。

Transforming growth factor -β1 （ TGF - β1 ） was reported to play an important role in the pathogenesls of asthma in many studies. It can stimulate the growth of fibroblast and give rise to fibrosis of lung tissues. Many scholars think that TGF - β1 is closely related to airway remodeling. It is a breakthrough to aim at TGF -β1 to find a way to intervene remodeling in asthma. Glucocorticoid （ Dexamethasone and Budesonide） can have an impact in some extent to airway remodeling. In addition,interferon-3, and some traditional chinese medicine such as ligustrazine, tripterygium wilfordii and ginkgo maybe effective, they all may ameliorate the progression of airway remodeling following redu-cing partial airway TGF -β1 expression.