SBA-15表面S-naproxen分子印迹聚合物微球的合成与分子识别特性

Molecular Recognition Capability and Synthesis of S-naproxen MolecularlyImprinted Polymers by Surface Polymerization on the Surface of SBA-15

以手性药物左旋萘普生(S-naproxen)为模板分子,四乙烯基吡啶(4-VPy)为功能单体,采用表面印迹法,以介孔材料SBA-15为载体合成了能选择性识别S-naproxen的分子印迹聚合物微球。扫描电镜及孔结构分析结果表明,所合成的分子印迹聚合物微球具有粒径均匀、孔径分布窄、比表面积大等特点;同时扫描电镜、X射线衍射和红外光谱分析结果表明载体表面形成了分子印迹聚合物层,Scatchard分析表明分子印迹聚合物在自组装过程中存在两类结合位点,聚合物高亲和力和低亲和力结合位点的最大表观结合容量分别为Qmax1=2.504μmol/g,Qmax2=16.680μmol/g;分子印迹聚合物的热力学研究表明,吸附过程可以自发进行。

Molecularly imprinted composite materials （MICMs） selective to S-naproxen were prepared on the surface of mesoporous silica sphere （SBA-15） by a surface imprinting technique with S-naproxen as the template and 4-vinylpyridine as the functional monomer. As observed by SEM and pore structure analysis, the microspheres coated with the synthesized molecularly imprinted polymers have a uniform particle size, narrow size distribution and high specific surface area. The polymer layer on SBA-15 can be determined by SEM, XRD and FT-IR spectroscopy. Scatchard analysis shows that two kinds of recognition sites are formed on the MICMS with the apparent binding capacities of 2. 504 μmol/g and 16. 680 μmol/g, respectively. Based on an isothermal binding thermodynamic investigation, the absorption to template is found to be spontaneous.