摘要
目的了解2007年我国不同地区12所教学医院肠杆菌属细菌的临床分布和耐药状况。方法全国12所教学医院2007年1—12月临床分离的1231株肠杆菌属细菌,采用K-B法进行药物敏感性试验,以CLSI2007版为判断标准。结果临床分离的1231株肠杆菌属细菌分离于呼吸道分泌物745株(60.5%)、尿液147株(11.9%)、血液66株(5.4%)和脑脊液11株(0.9%),其他无菌体液(胆汁、胸腹水等)39株(3.2%)。肠杆菌属细菌对头孢西丁耐药率最高(93.0%);对头孢噻肟和头孢他啶的耐药率较高(36.9%～37.7%);对头孢吡肟、阿米卡星、庆大霉素和环丙沙星耐药率较低(13.7%～28.0%);对亚胺培南和美罗培南耐药率最低,仅为0.9%。结论肠杆菌属细菌的耐药情况日趋严重,尤其是新出现了碳青霉烯类抗生素耐药株,各医院应采取相应的控制措施以遏制耐药株的增长。
Objective To investigate the distribution and antibiotic resistance clinical Enterobacter isolates. Methods A total of 1 231 clinical strains of Enterobacter spp were collected from 12 hospitals during January 1 through December 31, 2007. Antimicrobial susceptibility testing was performed with Kirby-Bauer method. The results were analyzed accord： ing to CLSI 2007 standards. Results The main source of Enterobacter was sputum （60. 5%, 745/1 231） and urine （11.9%, 147/1 231）, blood （5.4%, 66/1 231）, and cerebrospinal fluid （0. 9%, 11/1 231） followed by aseptic body fluid （3.2%, 39/1 231）. The resistance rate （93.0%） to cefoxitin was the highest. The rate of resistance to cefotaxime, and ceftazidime, was relatively higher （36. 9% to 37.7%）. However, the rate of resistance to cefepime, amikacin, gentamicin and ciprofloxacin was relatively lower （13.7% to 28.0%）. The rate of resistance to imipenem and meropenem was the lowest （0.9%）. Conclusions Antibiotic resistance of Enterobacter spp is serious in China. Especially, earbapenemsresistant Enterobacter isolates were identified. Every hospital should take effective control measures to curb the growth of resistant strains.
出处
《中国感染与化疗杂志》
CAS
2009年第3期201-206,共6页
Chinese Journal of Infection and Chemotherapy
关键词
肠杆菌属
阴沟肠杆菌
产气肠杆菌
碳青霉烯类
抗感染
耐药性
Enterobacter spp
Enterobacter cloacae
Enterobacter aerogenes
carbapenem
antimicrobial
antibiotic resistance
