运动适应中AMPK分子调控机制的研究进展

Progress in Research on Molecular Regulation Mechanism of AMP-Activated Protein Kinase in Adaptation to Exercise

运动应激导致机体骨骼肌细胞内的相对能量平衡状态遭到破坏,机体恢复相对能量平衡状态对机体运动能力的保持具有重要意义。AMPK在运动适应过程中对调节细胞能量代谢和物质代谢,维持细胞自稳态具有重要作用。在一次性运动中AMPK的激活具有运动强度依赖性和运动时间依赖性。AMP/ATP比值改变是运动适应过程中AMPK激活的主要机制,Cr/PCr比值、葡萄糖等细胞内其他能量物质状态、H+浓度变化和LKB1等骨骼肌AMPK上位激酶的变化对AMPK激活也有影响。阐明了在运动适应过程中AMPK分子调控机制方面的研究进展。

Exercise as a stress destroys the relative equilibria of energy in skeletal muscle cells. It is very important to recover the state of energy balance for the whole body to keep the capacity of exercise. AMPK plays a major role in the process of adaptation to exercise to regulate energy metabolism and material metabolism and to keep the homeostasis in skeletal muscle ceils. AMPK was activated by time and intensity dependence during a bout of exercise. The change of the ratio of AMP/ATP is the main molecular mechanism to activate AMPK in adaptation to exercise. Moreover,the ratio of Cr/PCr and the state of other energy material also regulate AMPK, such as glycogen and glucose etc. The concentration of H ＋ and the AMPKK→LKBI has certain significant effect on activation of AMPK. This review aims to outline the advanced research on molecular regulation mechanism of AMPK in adaptation to exercise.