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非小细胞肺癌中P-AKT、IGF-1蛋白表达

Expression of P-AKT, IGF-1 in Non-small Cell Lung Cancer
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摘要 [目的]探讨磷酸化蛋白激酶B(P-AKT)、胰岛素样生长因子1(IGF-1)在非小细胞肺癌(NSCLC)中的表达及临床意义。[方法]用免疫组化S-P法检测61例NSCLC及20例肺正常组织中P-AKT、IGF-1的表达,分析P-AKT、IGF-1表达及与NSCLC临床病理特征的关系。[结果]NSCLC中P-AKT阳性表达率为44.3%(27/61),明显高于在正常组织中的表达率(0,0/20),两者之间有显著性差异(χ2=13.28,P<0.05);P-AKT阳性表达与肿瘤的分化程度明显相关。NSCLC中IGF-1的表达明显高于正常组织(42.6%vs10.0%,χ2=7.09,P<0.05);IGF-1表达与肿瘤淋巴结转移、TNM分期明显相关。P-AKT与IGF-1表达呈正相关(r=0.633,P<0.05)。[结论]NSCLC中P-AKT和IGF-1的表达明显增高,它们可能参与肺癌的发生发展。 [Purpose] To investigate the expression of kiase B （P-AKT）, and insulin-like growth factor-1（IGF-1） in non-small cell lung cancer （NSCLC） and its clinical significance. [Methods] Expression of P-AKT and IGF-1 was detected by streptavidin-peroxidase （SP） method in 61 cases of NSCLC and 20 normal lung tissue. The relationship between P-AKT and IGF-1 expression and clinicopathological features of NSCLC was studied. [Results] P-AKT positive expression was 44.3% in NSCLC, which was significantly higher than that in normal tissue （0,0/20）（Х^2=13.28,P〈 0.05）. There was significant correlation between P-AKT expression and cell differentiation in NSCLC. IGF-1 expression was significantly higher than that in normal tissues （42.6% vs 10.0%, Х^2=7.09,P〈0.05）. The expression of IGF-1 correlated with lymph node metastasis, TNM staging. There was positive correlation between the expressions of P-AKT and IGF-1 （r=0.633,P〈0.05） in NSCLC. [Conclusion] The expression of P-AKT and IGF-1 in NSCLC is higher than that in normal tissue. It might participate in carcinogenesis of NSCLC.
作者 李侠 王玲 宋艳丽 高锡刚
机构地区 山东省职业病医院 山东大学齐鲁医院 山东省博兴县中医院
出处 《肿瘤学杂志》 CAS 2009年第8期715-718,共4页 Journal of Chinese Oncology
关键词 癌 非小细胞肺 蛋白激酶B 胰岛素样生长因子 carcinoma, non-small cell lung P-AKT IGF-1
分类号 R734.2 [医药卫生—肿瘤]
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参考文献10

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共引文献16

肿瘤学杂志
2009年 第8期

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