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ALCAM基因在肝癌中的表达及其临床意义 被引量：4

Expression of ALCAM in Hepatocellular Carcinoma and its Clinical Significance
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摘要 [目的]探讨活化白细胞黏附分子(ALCAM)基因在原发性肝细胞癌(HCC)中表达的特征及其临床意义。[方法]应用RT-PCR及免疫组化Elivision法检测ALCAM基因在42例肝癌组织及相应42例癌旁组织中的表达,分析其与HCC临床病理特征的相关性。[结果]RT-PCR显示HCC中ALCAMmRNA水平显著高于癌旁组织,Elivision法显示HCC中ALCAM蛋白的表达较癌旁组织明显升高,ALCAMmRNA表达水平及ALCAM表达与HCC组织分化程度及肝内转移有关,与患者性别、HBsAg状态、术前AFP水平、肿瘤包膜、肿瘤大小、癌肿数目无关。[结论]HCC中ALCAM基因的表达能促进HCC的发生、发展和转移,可作为判断HCC恶性程度、评价预后的指标。
作者 庄建良 柯少迎 潘群雄 苏子剑 庄奕煌 李明珠 王聪仁
机构地区 福建医科大学附属泉州市第一医院
出处 《肿瘤学杂志》 CAS 2009年第8期746-749,共4页 Journal of Chinese Oncology
基金 泉州市科技计划项目(2007Z27)
关键词 肝肿瘤 ALCAM基因 RT—PCR Elivision
分类号 R735.7 [医药卫生—肿瘤]
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参考文献11

  • 1Degen W, van Kempen L, Gijzen E, et al. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)[J]. Am J Pathol, 1998,152(3):805-813.
  • 2van Kempen LC, van den Oord JJ, van Muijen GN, et al. Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin[J]. Am J Pathol, 2000, 156(3):769- 774.
  • 3Kristiansen G, Pilarsky C, Wissmann C, et al. ALCAM/ CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions [J]. Prostate, 2003, 54(1):34-43.
  • 4King JA, Ofori-Acquah SF, Stevens T, et al. Activated leukocyte cell adhesion molecule in breast cancer: prognostic indicator[J].Breast Cancer Res,2004,6(5):478-487.
  • 5Burkhardt M, Mayordomo E, Winzer KJ, et al. Cytoplasmic over expression of ALCAM is prognostic of disease progression in breast cancer[J]. J Clin Pathol, 2006, 59(4): 403 -409.
  • 6Weichert W, Knosel T, Bellach J, et al. ALCAM/CD166 is over expressed in colorectal carcinoma and correlates with shortened patient survival [J]. J Clin Pathol, 2004, 57(11): 1160-1164.
  • 7Tomita K, van Bokhoven A, Jansen CFJ, et al. Activated leukocyte cell adhesion molecule (ALCAM) expression is associated with a poor prognosis for bladder cancer patients[J]. Uro Oncology, 2003, (3): 121 - 129.
  • 8Verma A, Shukla NK, Deo SV, et al. MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma [J]. Oncology, 2005, 68(4-6):462-470.
  • 9Davies sR, Dent C, Watkins G, et al. Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis[J]. Oncol Rep, 2008, 19(2):555-561.
  • 10Mezzanzanica D, Fabbi M, Bagnoli M, et al.Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients[J]. Clin Cancer Res, 2008, 14(6):1726-1733.

共引文献1

同被引文献56

  • 1庄建良,苏子剑,许荣誉.活化白细胞黏附分子及其与肿瘤侵袭转移的关系[J].国际病理科学与临床杂志,2006,26(6):479-482. 被引量：6
  • 2庄建良,苏子剑,潘群雄,许荣誉,李明珠.大肠癌活化白细胞黏附分子的表达及其与肿瘤细胞增殖和血管生成的关系[J].国际肿瘤学杂志,2007,34(2):150-153. 被引量：5
  • 3Klein WM, Wu BB, Zhao S, et al. Increased expression of stem cell in malignant melanoma. Mol Pathol, 2007, 20: 102-107.
  • 4Davies SR, Dent C, Watkins G, et al. Expression of the cell to cell adhesion molecule, ALCAM in breast cancer patients and the potential link with skeletal metastasis. Oncol Rep, 2008, 19: 555-561.
  • 5Kahlert C, Weber H, Mogler C, et al. Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relaps. Br J Cancer, 2009, 101: 457-464.
  • 6Mezzanzanica D, Fabbi M, Bagnoli M, et al. Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients. Clin Cancer Res, 2008, 14: 1726-1733.
  • 7Kurman R J, Shih IM. The origin and pathogenesis of epithelial ovarian cancer:a proposed unifying theory. Am J Surg Pathol, 2010, 34: 433- 443.
  • 8VAN KEMPEN L C, VAN DEN OORD J J, VAN MUIJEN G N, et al. Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin [ J ]. Am J Pathol, 2000, 156(3) : 769 -774.
  • 9KRISTIANSEN G, PILARSKY C, WISSMANN C, et al. AL- CAM/CD166 is up - regulated in low - grade prostate cancer and progressively lost in high - grade lesions [ J ]. Prostate, 2003, 54 (1) : 34 -43.
  • 10VERMA A, SHUKLA N K, DEO S V, et al. MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esopha- geal squamous cell carcinoma [ J ]. Oncology, 2005, 68 ( 4/6 ) : 462 - 470.

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肿瘤学杂志
2009年 第8期

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