沈阳地区健康成人肺功能与国外预计值比较分析

The difference between oversea predicted values and Chinese healthy adult measurements of spirometry in shenyang

目的探讨常用国外肺功能预计值是否适用于沈阳地区。方法检测2005年3月至2006年5月中国医科大学盛京医院287名成人健康体检者肺功能,其中筛选出230名受试者肺功能结果与Knudson等常用国外肺功能预计值进行比较。结果男性(154例)实测值分别为肺活量(VC)(4.4±0.7)L、用力肺活量(FVC)(4.3±0.7)L、第一秒用力呼气容积(FEV1)(3.5±0.6)L、呼气峰流量(PEF)(7.1±1.9)L/s、最大呼气中段流量(FEF25%～75%)(3.6±1.1)L/s、深吸气量(IC)(2.8±0.7)L,各项指标较国外预计值偏低2%～26%,除Kory预计公式中VC预计值及Morris预计公式中FEF25%～75%预计值外,其他检测指标国外预计值与实测值差异均有统计学意义;女(76例)实测值分别为VC(3.1±0.7)L、FVC(3.1±0.7)L、FEV1(2.5±0.6)L、PEF(5.0±1.4)L/s、FEF25%～75%(2.6±0.9)L/s、IC(2.1±0.7)L,各项指标较国外预计值多数偏低2%～21%,其中VC、FVC的Morris预计值、FEV1的Kory、Knudson预计值、PEF及FEF25%～75%指标的国外预计值、IC的Roca预计值分别与实测值比较,差异有统计学意义。结论Knudson或ECCS预计值较接近实测沈阳地区健康受试者的肺功能实测值大部分低于常用国外预计值。在Knudson或ECCS预计公式中加用校正系数,可更准确地对沈阳地区受试者的肺功能进行评价。

Objective To evaluate if the difference between oversea predicted values and healthy adult measurements of spirometry in shenyang. Methods 287 healthy adult volunteers underwent pulmonary function test. The measurements of spiromenty of 230 selected objects were compared to conventional oversea predicted values. Results In male group（ 154 objects） ,the measured values were as follows ： VC （4.4± 0. 7 ） L, FVC （ 4. 3 ± 0. 7 ） L, FEVI （ 3.5 ± 0. 6 ） L, FEF25%-75% （ 3.6 ± 1.1 ） L/s, PEF （7.1 ± 1.9 ） L/s, IC （ 2. 8 ± 0. 7 ） L, respectively. In female group （76 objects） , the measured values were as follows：VC （3.1 ±0.7）L,FVC （3. 1±0. 7）L,FEV1 2.5 ±0. 6（L） ,FEF25% .FEF 25%-75% （2.6 ±0. 9） L/s,PEF（5.0 ± 1.4） L/s, IC （2. 1 ± 0.7 ） L respectively. The measurements were 2% - 26% and 2% - 21% lower than the predicted values in male and female respectively. The major compared values had significant difference. Conclusion The major measured values of spirometry in healthy adult in shenyang were significantly lower than the oversea predicted values. Knudson or ECCS regression equations with appropriate correction factor were suggested to use in shenyang.