丙氨酸氨基转移酶正常的慢性乙型肝炎病毒感染者的处理建议

Recommendations for treatment of chronic hepatitis B virus infected patients with normal alanine aminotransferase level

丙氨酸氨基转移酶(ALT)是确定慢性乙型肝炎病毒(HBV)感染患者是否需要治疗的重要指标。但最近的数据显示一些ALT水平正常的慢性HBV感染者中大多存在不同程度的肝脏组织学改变,甚至已发展至肝硬化和肝癌。本文结合HBV感染的自然史、国内外研究的最新进展及目前的慢性乙型肝炎患者抗病毒治疗现状就ALT正常的慢性HBV感染者提出合理的处理建议。

Alanine aminotransferase （ALT） levels have traditionally been used for making treatment decisions in chronic hepatitis B virus（CHBV） infected patients. But recent researches revealed that a significant proportion of CHBV infected patients with normal ALT level have exsited liver injury in various degrees, in which some patients even have been progressed to cirrhosis and hepatic carcinoma. This article would give some recommendations for treatment of CHBV infected patients with normal ALT based on the natural history of CHBV infection, the latest development of study at home and abroad, and the current anti-viral treatment station of CHBV infected patients.