期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张素1-7:肾素-血管紧张素系统新调节因子 被引量：4

Angiotensin(1-7):a novel renin angiotensin system mediator
下载PDF
导出
摘要 血管紧张素(Ang)1-7是肾素-血管紧张素系统的新调节因子,它能够拮抗AngⅡ的扩血管和促增殖等效应,并对肾脏发挥复杂的调节作用。通过药物作用干预血管紧张素酶2-Ang-(1-7)-Mas轴的功能,将会为心血管疾病、肾脏、肝脏疾病和糖尿病的治疗提供新的可能。 As a novel renin angiotensin system mediator Angiotensin（ 1-7 ） antagonizes vasodilation and proliferative effects of angiotensin Ⅱ and exerts complex renal actions. We also speculated the possibility of new drugs for the treatment of angiocardiopathy, nephropathy, hepatopathy and diabetic mellitus by interfering with ACE2 -angiotensin- （ 1-7 ） -Mas axis.
作者 卜乐 刘志民
机构地区 第二军医大学第二附属医院内分泌科
出处 《国际内科学杂志》 CAS 2009年第8期480-483,494,共5页 International Journal of Internal Medicine
基金 国家重点基础研究发展计划(973)资助项目(2005CB523304)
关键词 血管紧张素1-7 MAS受体 血管紧张素酶2 肾素-血管紧张素系统 Angiotensin （ 1-7 ） Mas receptor Angiotensin-converting enzyme 2 Renin angiotensin system
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1Santos RA, Ferreira A J, Simoes E, et al. Recent advances in the angiotensin- converting enzyme 2- angiotensin (1-7 )- Mas axis. Exp Physiol,2008,93 (5) :519-527.
  • 2Trask AJ,Averill DB, Ganten D, et al. Primary role of angiotensin converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenie Ren-2 hypertensive rats. Am J Physiol Heart Circ Physiol,2007,292(6) :3019-3024.
  • 3Kostenis E, Milligan G, Christopoulos A, et al. G-proteincoupled receptor Mas is a physiological antagonist of the angiotensin Ⅱ type 1 receptor. Circulation, 2005, 111 ( 14 ) : 1806-1813.
  • 4Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-convetting enzyme 2 is an essential regulator of heart function. Nature, 2002,417 ( 6891 ) : 822 -828.
  • 5Castro CH, Santos RA, Ferreira AJ,et al. Effects of genetic deletion of angiotensin- (1-7) receptor Mas on cardiac function during ischemia/reperfusion in the isolated perfused mouse heart. Life Sci,2006,80(3) :264-268.
  • 6Mendes AC, Ferreira AJ, Pinheiro SV, et al. Chronic infusion of angiotensin-(1-7) reduces heart angiotensin Ⅱ levels in rats. Regul Pept ,2005,125 ( 1-3 ) :29-34.
  • 7Oudot A, Martin C, Busseuil D, et al. NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging. Free Radic Biol Med, 2006,40 (12) :2214-2222.
  • 8Rastelli VM, Oliveira, MA, dos Santos R, et al. Lack of potentiation of bradykinin by angiotensin-( 1-7 ) in a type 2 diabetes model: role of insulin. Peptides, 2007, 28 ( 5 ) : 1040-1049.
  • 9Lara LS, De Carvalho T, Leao-Ferreira LR, et al. Modulation of the (Na ( + ) + K ( + )ATPase activity by Angiotensin-(1- 7) in MDCK cells. Regal Pept,2005,129(1-3) :221-226.
  • 10Pinheiro SV, Simoes AC, Sampaio WO, et al. Nonpeptide AVE 0991 is an angiotensin-( 1-7 ) receptor Mas agonist in the mouse kidney. Hypertension,2004,44 (4) :490-496.

同被引文献45

  • 1杜军,陈长勋.血管紧张素(1-7)的心血管效应[J].中国药理学通报,2007,23(5):572-574. 被引量：12
  • 2Valdes G, Neves LA, Anton L, et al. Distribution of angiotensin (1 -7) and ACE2 in human placentas of normal and pathologicalpregnancies [ J ]. Placenta, 2006, 27 (2-3): 200-207.
  • 3Kostenis E, Milligan G, Christopoulos A, et al. G- protein - coupled receptor Mas is a physiological antagonist of the angiotensin 1I type 1 receptor [ J]. Circulation, 2005, 111 (14): 1806-1813.
  • 4Shlomo K, Mariell K, Aviva GL, et al. ACE2 of the heart : from angiotensin I to angiotensin ( 1 - 7 ) [ J ]. Circ Res, 2007, 73:463-469.
  • 5Dias -peixolo MF, Santos RA, Gomes ER, et al Molecular mechanisms involved in the angiotcnsin ( 1 - 7) / Mas signaling pathway in eardiomyocytes [ J] Hypertension, 2008, 52:542-548.
  • 6Santos RA, Simoese Silva AC, Marie C, et al. Angiotensin ( 1 - 7) is an endogenous ligand for the G protein -coupled receptor Mass [ J ]. Proc Natl Acad Sci USA, 2003, 100 (14): 8258 -8263.
  • 7Lemos VS, Silva DM, Walther T, et al. The endothclium2 dependent vasodilator effect of the nonpeptide an- giotensin (1 -7) mimic AVE0991 is abolished in the aorta of Mas2knockout mice [J]. Cardiovasc Pham acol, 2005, 46 (3): 274-279.
  • 8Sampaio WO, Souza dos Santos RA, Faria - Silva R, et al. Angiotensin ( 1 -7) through receptor Mas mediates endothelial nitric oxide synthase activation Akt - dependent pathways [ J ]. Hypertension, 2007, 49 (1): 184--192.
  • 9Castro CH, Santos RA, Ferreira AJ, et al. Evidence for a fun tional interaclion of the angiotensin - ( 1 - 7) receptor Mas with AT1 and AT2 receptors in the mouse heart [J]. Hypertension, 2005, 46 (10): 937 - 942.
  • 10Gallagher PE, Ferrario CM, Tallant EA, et al. EA -MAP kinase/phos -phatase pathway mediates the regulation of ACE2 by angiotensin peptides [J]. Am J Physiol Cell Phsiol, 2008, 295 (5): 1169 -1174.

引证文献4

二级引证文献2

国际内科学杂志
2009年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部