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CD4^+ CD25^+调节性T细胞和Graves病 被引量：2

The relationship between CD4^+ CD25^+ regulatory T cell and Graves' disease
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摘要 Graves病(GD)是一种自身免疫性甲状腺疾病,其发病机制涉及到细胞免疫与体液免疫的异常。新近的研究发现,调节性T细胞(Treg)能够抑制那些逃避的自身反应性T细胞克隆的活性和功能,在自身免疫性甲状腺疾病发病的发生发展中扮演重要角色。在GD的发病过程中,不仅有自身反应性T细胞的参与,也可有抑制免疫反应的自身反应性Treg的参与。而Treg及其表面表达分子叉头/翅膀状螺旋(Foxp3)基因、糖皮质类固醇激素诱导的肿瘤坏死因子受体家族相关受体(GITR)及细胞毒性T淋巴细胞相关抗原(CTLA)-4的高表达可减少GD等自身免疫性疾病的发生。因此提高Treg的反应性,进而抑制自身免疫,是GD很有希望的治疗策略。 Graves＇ disease （GD） is an autoimmune disorder with abnormal cellular and humoral immune process. Accumulating data has showed that regulatory T cells （Treg） participated in the inhibition of reactive T cells, and played an important role in autoimmune thyroid diseases. As GD is concerned, autoimmune processes are attributable to not only autoaggressive T-cell response but also autoreactive regulatory components. Enhancing Treg responsiveness or their expressed molecules such as Foxp3, Glucocorticoid induced tumor necrosis factor receptor and Cytotoxic Tlymphocyte associated antigen 4, therefore, maybe a promising approach for the treatment of autoimmune thyroid diseases including GD.
作者 李杰 刘超
机构地区 南京医科大学第一附属医院内分泌科
出处 《国际内科学杂志》 CAS 2009年第8期495-496,F0003,F0004,共4页 International Journal of Internal Medicine
关键词 调节性T细胞 GRAVES病 叉头/翅膀状螺旋转录因子 糖皮质类固醇激素诱导的肿瘤坏死因子受体家族相关受体 细胞毒性T淋巴细胞相关抗原-4 Regulatory T cell Graves disease Foxp3 GITR CTLA-4
分类号 R581.1 [医药卫生—内分泌]
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参考文献25

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同被引文献21

  • 1刘丽萍,李雷,赵丽瑞,高志红,郑师陵.太极拳运动对中老年女性身体免疫功能的影响[J].中国临床康复,2005,9(40):98-99. 被引量：7
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国际内科学杂志
2009年 第8期

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