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普利醇药理作用的研究进展 被引量：5

Research progress on pharmacological effects of policosanol
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摘要 普利醇(policosanol)是一种从精炼甘蔗蜡中提取出来的长链脂肪醇混合物,其主要成分是二十八烷醇。具有抗心脑缺血、降低血浆胆固醇水平、抑制血小板聚集、抗脂质过氧化、抑制血管内膜增生和平滑肌增殖以及血管新生等作用,安全性和耐受性均很好。 Policosanol is a mixture of long chain aliphatic alcohols originally derived from purified sugar cane wax, which mainly contains octacosanol. It can protect myocardium or brain against ischemic injury, lower plasma cholesterol level, reduce platelet aggregation, and inhibit lipid peroxidation, smooth muscle cell proliferation and angiogenesis. It shows impressive safety and tolerance. This paper reviews the research progress on pharmacological effects of policosanol.
作者 易思思 张凯 胡长平
机构地区 中南大学药学院药理学系 高血压病研究所
出处 《国际病理科学与临床杂志》 CAS 2009年第4期342-345,共4页 Journal of International Pathology and Clinical Medicine
基金 中南大学"升华学者计划"(第四批)~~
关键词 普利醇 药理作用 最新进展 policosanol pharmacology research progress
分类号 R96 [医药卫生—药理学]
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参考文献30

  • 1Gouni-Berthold I, Berthold HK. Polieosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent [ J]. Am Heart J, 2002, 143(2) :356-365.
  • 2Marrero D, Mas R, Fernandez I, et al. In vitro and vivo study of octacosanol metabolism [J]. Arch Med Res, 2005, 36(2):113- 119.
  • 3崔艳丽,赵秀丽.新型调脂药普利醇的药理和临床研究[J].中国新药杂志,2006,15(6):480-483. 被引量：3
  • 4Castano G, Mas R, Fernandez JC, et al. Effect of policosanol on older patients with hypertension and Type Ⅱ hypercholesterolaemia [J]. Drugs R D, 2002, 3(3) :159-172.
  • 5Jargin SV. Discussion of evaluation of cholesterol-lowering and antioxidant properties of sugar cane policosanols in hamsters and humans[ J ]. Appl Physiol Nutr Metab, 2009, 34( 1 ) :75.
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  • 7Francini-Pesenti F, Brocadello F, BeltramoUi D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-rosistant hypercholesterolaemia: a double blind, controlled study [ J ]. Complement Ther Med,2008, 16 (2) :61-65.
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二级参考文献37

  • 1普伐他汀临床研究协作组.普伐他汀与吉非贝齐治疗原发性高胆固醇血症的临床比较研究[J].中华心血管病杂志,1995,23(6):429-433. 被引量：18
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  • 4MARRERO D,MAS R ,FERNANDEZ I,et al. In vitro and in vivo study of octacosanol metabolism [ J ]. Arch Med Res,2005,36 ( 2 ) :113 - 119.
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  • 8McCARTY MF. Policosanol safely down-regulates HMG-CoA reductase-potential as a component of the Esselstyn regimen [ J ].J Chromatogr B Biomed Sci Appl, 2001,762( 1 ) :43 -49.
  • 9MENENDEZ R, AMOR AM, RODEIRO I,et al. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts [J].Arch Med Res, 2001,32( 1 ) :8 - 12.
  • 10MENENDEZ R, MAS R, AMOR AM,et al. Effects of policosanol treatment on the susceptibility of low density lipoprotein(LDL) isolated from healthy volunteers to oxidative modification in vitro [ J ], Br J Clin Pharmacol, 2000,50 (3) :255 -262.

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国际病理科学与临床杂志
2009年 第4期

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