皮质抑素在免疫系统中的作用

Role of cortistatin in the immune system

皮质抑素(cortistatin,CST)是一种新的生长抑素家族神经内分泌多肽,广泛分布于中枢神经系统、内分泌器官及免疫系统中,能够与生长抑素受体、生长素受体及MrgX2受体结合,发挥调节神经内分泌功能、诱导免疫耐受及抑制炎症反应的作用。作为一种抗炎因子,CST可能在败血症、克罗恩病及类风湿关节炎的治疗中发挥作用。CST亦能够抑制血管内皮细胞增殖及迁移,提示CST在心血管疾病的发生和治疗中可能具有一定的意义。

Cortistatin（CST） is a new member of somatostatin neuropeptide family, widely distributed in central nervous system, peripheral endocrine organs and immune organs. It＇s able to bind to somatostatin receptors, gbrelin receptors and MrgX2 receptors. CST has been shown to regulate the neuroendocrine functions, to induce immune tolerance as well as to inhibit inflammatory reactions. CST can function as an anti-inflammatory factor with therapeutic potential in sepsis, Crohn＇ s disease and rheumatoid arthritis. Since it can inhibit the proliferation and migration of vascular endothelial cells, CST might also have clinical significances in the development and therapy of cardiovascular diseases