摘要
目的研究复方昆布颗粒剂β-环糊精包合挥发油的最佳工艺;考查包合物的稳定性。方法采用正交试验设计,以挥发油得率、包合物含量为测定指标。结果最佳包合工艺为β-环糊精:复方昆布颗粒挥发油=12:1(g·mL^(-1)),包合温度为50~60℃,包合时间为2h;挥发油加水提取2次,一煎加水量为13倍,沸后煎煮时间为1.0h,二煎加水量为11倍,沸后煎煮时间为1.0h;A_2B_1为优选出的最佳提取工艺方案。结论本工艺包合物含量较高,工艺稳定且操作简便,可应用于复方昆布颗粒的生产中。
Objective To study the best preparation technique of compound Thallus laminaria granules volatile oil-β-cyclodextrin clathrate and examine the stability of the clathrate. Methods The orthogonal design method was used to optimize the formulation. The yeild of the volatile oil and the content of the clathrate were used as the test target. Results The best preparation process was as follows:β-eyclodextrin ;compound Thallus laminaria = 12 : 1 (g · mL^-1 ) ,at 50-60℃ for 2 hours. Making distillation twice while adding water to the first decoction,steaming lh after boiling; A2 B1 was the best extraction scheme. Conclusion The preparation process can be a scheme to obtain the clathrate with high content of effective component,which can be used in the preparation of the clathrate.
出处
《中国海洋药物》
CAS
CSCD
2009年第4期40-42,共3页
Chinese Journal of Marine Drugs
关键词
复方昆布颗粒
挥发油
Β-环糊精
包合物
工艺
compound Thallus laminaria granules
volatile oil
β-cyclodextrin
clathrate
technology