^(131)I与抗甲状腺药物治疗甲亢的疗效比较

Therapeutic Effect Comparison of ^(131)I and Anti-thyroid Drugs on Patients with Hyperthyroidism

目的:比较^(131)I与抗甲亢药物(ATD)治疗甲亢的疗效。方法:选择首诊的甲亢患者200例,随机分为两组:^(131)I治疗组与ATD对照组各100例。观察^(131)I与ATD治疗后突眼、甲减及甲亢复发的情况,并观察^(131)I与ATD治疗甲亢并发症的疗效及不良反应。结果:^(131)I与ATD组发生甲减的差异无统计学意义。两组突眼的转归也无差异。^(131)I治疗复发率明显低于ATD组。^(131)I治疗甲亢心脏病疗效优于ATD。^(131)I治疗出现肝损伤、白细胞减少等不良反应低于ATD。结论:^(131)I治疗甲亢是安全有效的,其综合疗效优于抗甲亢药物。

Objective： To investigate the effects of ^131I and anti-thyroid drugs （ATD） on patients with hyperthyroidism. Method： Two hundreds patients with hyperthyroidism were divided into ^131I group （100 cases） and ATD group（ 100 cases）. A comparison of curative efficacy, incidence of hypothyroidism, relapse and exophthalmos between two groups were performed. Result： The incidence of hypothyroidism and exophthalmos were no statistical difference between two groups（ P 〉 0.05 ）. Compared to ATD group, the incidence of hepatic injury and leukopenia were lower in ^131I group（ P 〈 0.05 ）. ^131I was more effective in treatment of hyperthyroid cardiopathy and relapse of hyperthyroidism was lower in ^131I group（ P 〈 0.05 ）. Conclusion： ^131I is more effective and safety than anti-thyroid drugs （ATD） in treatment of hyperthyroidism.