2型糖尿病血清β2-微球蛋白的临床意义

Relationship between type 2 diabetes mellitus and β2-micro globulin in serum

目的探讨2型糖尿病与血清β2微-球蛋白的关系。方法采用放射免疫分析法对30例正常人,72例2型糖尿病患者(其中早期糖尿病肾病35例,简写为DN,糖尿病未出现肾损害37例,简写为NDN)进行血清β2微-球蛋白测定,并分组进行分析。结果DN组血清β2微-球蛋白含量明显高于对照组,P<0.01,差异有统计学意义。对照组、NDN组及DN组血清β2微-球蛋白的含量逐渐递增,NDN组与对照组相比,P>0.05,差异无统计学意义。结论血清β2微-球蛋白在DN组明显升高。

Objective To investigate the relationship between type 2 diabetes mellitus and β2-micro globulin in serum Methods The content of the serum β2-micro globulin in 30 healthy people and in 72 patients with type 2 diabetes mellitus （35 with diabetes nephropathy, DN and 37 without nephropathy, NDN） measured using radiation immunity analysis （RIA）and was compared among the three groups. Results The containt of β2-micro globulin in serum in diabetes nephropathy was higher than that in the control group, with the significant difference（ P 〈 0. 01 ）. Thecontaint of β2-micro globulin increases gradually from the control group to NDN and DN group and there was no significant difference between the control group and NDN group（P 〉 0. 05 ）. Conclusions The serum β2-micro globulin in diabetes nephropathy is more higher , meaning it is more important＇to forecast diabetes nephropathy.