四氢叶酸辅酶结构和性能的模拟及取代一碳单元转移反应的研究

Mimicking of Structure and Properties of Tetrahydrofolic Coenzyme and Study on Their Substituted One - Carbon Unit Transfer Reactions

本工作摸拟了四氢叶酸辅酶的结构和反应性能,合成了模型化合物碘化1,2-二甲基-3-对甲氧苯磺酰基咪唑琳,研究了模型化合物与单官能团亲核体、双官能团亲核体相作用,以甲酸、甲醛氧化态转移取代一碳单元[≡C—CH_3,=C(CH_3)CH_2NO_2]的反应,部分反应生成了咔啉类生物碱衍生物和其它杂环类化合物.

Substituted imidazolinium salt, 1,2- dimethyl - 3 - (p - methoxybenzenesulfonyl) -imidazolinium iodide,as a tetrahydrofolate model in terms of the ability to transfer a substituted one- carbon unit (ethylidyne,nitromethylethylidene) at the level of formate or formaldehyde,has been synthesized by mimicking the structure and property of tetrahydrofolate coenzyme. The model compound can react with a variety of mono - and bif unctional nucleophiles and lead to some carboline alkaloids and other heterocyclic compounds.