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雌、孕激素对早孕蜕膜基质细胞中Mig和IP-10表达的影响

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摘要 母胎平衡机制一直是生殖研究领域的热点和难点之一。有研究证实，母胎界面中表达的趋化因子-趋化因子受体系统在保持母胎平衡中起重要作用。CXC类趋化因子Mig和IP-10在早孕蜕膜上皮及基质细胞中高表达，其表达变化与蜕膜中免疫细胞聚集和滋养细胞生物学行为有关。调控母胎界面中趋化因子表达的机制目前尚不完全清楚，性激素是调控母胎平衡的主要内分泌因素，本研究通过观察雌、孕激素对早孕蜕膜基质细胞中Mig、IP-10表达的影响，进一步揭示Mig和TP-10在母胎平衡中的作用。
作者 白晓霞 孔北华 曲迅 张友忠
机构地区 浙江大学医学院附属妇产科医院产科 山东大学齐鲁医院妇产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2009年第8期617-619,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 蜕膜基质细胞 IP-10 早孕蜕膜 孕激素 细胞生物学行为 母胎界面 平衡机制 趋化因子
分类号 R686 [医药卫生—骨科学]
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参考文献9

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二级参考文献8

  • 1Hanna J, Wald O, Goldman-Wohl D, et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16^- human natural killer cells. Blood, 2003,102 : 1569-1577.
  • 2Red-Horse K, Drake PM, Gunn MD,et al. Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. Am J Pathol, 2001,159:2199-2213.
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  • 8Daikoku N, Kitaya K, Nakayama T, et al. Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. Fertil Steril, 2004,81 : 876-881.

共引文献7

中华妇产科杂志
2009年 第8期

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