黑蚂蚁粉对小鼠免疫功能的影响

Effects of Black Ant Powder on Immune Function of Mice

目的:研究黑蚂蚁对小鼠非特异性免疫和特异性免疫功能的影响。方法:根据黑蚂蚁的用药量将小鼠分成高、中、低剂量及空白对照组,黑蚂蚁粉给药量按小鼠体重1.5 g/kg、0.75 g/kg、0.375 g/kg计算,连续10 d灌胃给药后,测定各组小鼠的体重、胸腺和脾脏重量,计算胸脾指数;检测中性粒细胞的吞噬率、T淋巴细胞E花环形成率及小鼠的溶血素效价和脾细胞介导的羊红细胞分光光度计定量测定法(QHS)。结果:与对照组比较,高、低剂量组小鼠体重明显下降(P<0.05),中剂量组小鼠脾脏指数明显升高(P<0.05),高剂量组小鼠的溶血素效价显著升高(P<0.01)。结论:黑蚂蚁能够影响小鼠的非特异性免疫和特异性免疫功能。

Objective： To study the influence of black ants （Polyrhachis vicina Roger） on specific and non-specific immune function of mice. Methods： Eighty mice were randomly divided into high, middle, and low dosage groups which were orally given 1.5 g/kg, 0.75 g/kg, 0.375 g/kg of ant powder respectively, twice a day for 10 days. A blank control group was set up which was given water instead. Body weight, thymus weight and spleen weight were measured. Thymus indexes （TI） and spleen index （SI） were calculated. Neutrophil phagocytose rate, Ea and Et rosette formation rate of T lymphocytes, and hemolysin titre were detected. QHS values were achieved with spleen cell mediated sheep red cell spectrophotometer quantitative assay. Results： Mouse body weights were significantly lower in high and low dose groups than that of control group （ P 〈 0.05 ） ; Spleen index in middle dose group （ P 〈 0.05 ） and hemolysin titer in high dose group （ P 〈 0.01 ） were obviously higher than those in control group. Conclusion： Black ants can affect immune function of mice.