对位取代的1,2-二苯基乙烯的合成及其不对称二羟基化反应

Synthysis of para Substituted 1,2 Diphenylethene and Its Asymmetric Dihydroxylation

近年来，人们对催化不对称二羟基化反应进行了广泛和深入的研究［１］．前文［２］曾报道了邻位取代的（Ｅ）－１，２－二苯乙烯的不对称二羟基化反应．本文探讨了对位取代的（Ｅ）－１，２－二苯乙烯类化合物的合成，并采用改进了的Ｓｈａｒｐｌｅｓｓ方法进行不对称二羟...

The para substituted (E) stilbenes 2a—2e were prepared respectively by Wittig reaction and nucleophilic substitution in 59%～80% yields. The asymmetric dihydroxylation was carried out by the modified Sharpless method. The amount of OsO 4 was increased to 1%(mole ratio) and the amount of ligand to 5%(mole ratio). All asymmetric dihydroxylation was performed at 0 ℃, affording the corresponding chiral 1,2 diol in 77%～87% yield with 82%～93% e.e. .