神经精神狼疮的诊断与治疗

Neuropsychiatric lupus:An update

在文献回顾的基础上,分析神经精神狼疮的临床表现、病理生理机制、诊断、治疗及预后。临床上,脑脊液、脑电图及脑影像学检查可提高本病诊断的敏感性,较大剂量的激素、免疫抑制剂及抗凝治疗,尤其是对合并症的处理仍是本病治疗的关键。但是,由于本病的临床多样性,如何维持其长期临床缓解,特别是提高生存质量,仍是今后重点需要解决的难题。

This article discusses the status quo of the researches on neuropsychiatric lupus, including its pathophysiological mechanism, clinical manifestation, diagnosis, treatment and prognosis. Cerebrospinal fluid examination, electroencephalography and brain imaging could improve the sensitivity of the diagnosis of neuropsychiatric lupus. Aggressive immunosuppressive agents, high-dose corticosteroids and anticoagulants remain the key to the therapy. However, future researches should focus on the control of long-term relapse and the improvement of the quality of life.