乌司他丁对心脏直视手术患者围术期血清呼吸指数和白细胞介素-6的影响

Effects of ulinastatin on RI and IL-6 in patients undergoing open heart surgery

目的探讨乌司他丁对心脏直视手术患者围术期血清呼吸指数(RI)和白细胞介素-6(IL-6)水平的影响。方法28例择期瓣膜置换术患者随机均分为乌司他丁组(Ⅰ组)和对照组(Ⅱ组)。分别测定中心静脉开放后(T1)、心肺转流(CPB)前即刻(T2)、主动脉开放即刻(T3)、1h(T4)、2h(T5)、18h(T6)6个时点血清RI和IL-6。结果与T1时相比,T2时Ⅱ组IL-6明显升高(P<0.05),亦明显升高Ⅰ组(P<0.05)。与T1时相比,T2、T4～T6时两组RI均明显升高(P<0.05),T5时Ⅱ组明显高于Ⅰ组(P<0.05)。结论乌司他丁能抑制IL-6释放,起到一定的肺保护作用。

Objective To investigate the effects of ulinastatin on repiratory index（RI） and interleukin-6（ IL-6 ） in patients undergoing open heart surgery. Methods Twenty-eight patients undergoing cardiac valve replacement were randomly allocated to two groups of ulinastatin（U） and control（C） with 14 cases each. Blood samples were taken before operation （T1）, before CPB（T2 ） , at 1 min（Ta）,1h（T4）, 2 h（T5） and 18 h（T6） after aorta unelamping. Results IL-6 of group C was significantly higher at T2 than that at T1 and that of group U at T2 （P〈0. 05）. Compared to that at T2, RI of both groups was significantly higher at T2 ,T4 -T6 （P〈0. 05）. RI at T5 was higher in group C than that in group U（P〈0. 05）. Conclusion Ulinastatin has a certain protective effect on the lungs through reducing the relief of IL-6.